Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 6/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | ARG1 | P05089 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | GCLC | P48506 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28097 | 0.88 | — | — | |
| Succinic Acid SCHEMBL29572406 | 0.87 | FFAR3 (0.48) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Sulfuric Acid SCHEMBL29485026 | 0.86 | CA2 (0.41) | CA2CA1CA12CA14MEN1 | |
| Hydrochloric Acid SCHEMBL8554410 | 0.85 | — | — | |
| Methylamine SCHEMBL27815740 | 0.85 | CA2 (0.44) | CA2CA1CA12CA14CA9 | |
| SCHEMBL5102024 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL27834557 | 0.85 | — | — | |
| Bicarbonate SCHEMBL9491659 | 0.84 | CA2 (0.46) | CA2CA1MEN1TSHRKMT2A | |
| Trifluoroacetic Acid SCHEMBL5310917 | 0.84 | FAAH (0.39) | CA2CA1CA12ARG1MEN1 | |
| Ethanesulfonic Acid Amide SCHEMBL9491342 | 0.82 | FFAR3 (0.41) | CA2FFAR3HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282079-B1 | COATING COMPOSITION WITH IMPROVED RUST-PREVENTING PROPERTIES FOR USE IN PREPARING LUBRICATED STEEL PRODUCTS | NIPPON OIL AND FATS COMPANY, LIMITED (JP) | 1993-03-03 | — | — | EP | claimed |