Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9494860 | 0.87 | LMNA (0.41) | ALDH1A1MEN1KMT2AGAATSHR | |
| SCHEMBL9494856 | 0.87 | LMNA (0.41) | ALDH1A1MEN1KMT2AGAATSHR | |
| SCHEMBL9493049 | 0.79 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2AGAATSHR | |
| SCHEMBL9493054 | 0.79 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2AGAATSHR | |
| SCHEMBL9494274 | 0.72 | LMNA (0.52) | ALDH1A1MEN1KMT2AGAATSHR | |
| SCHEMBL9494278 | 0.72 | LMNA (0.52) | ALDH1A1MEN1KMT2AGAATSHR | |
| SCHEMBL17813824 | 0.67 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2AGAATSHR | |
| Phosphoric Acid SCHEMBL11090384 | 0.66 | LMNA (0.49) | ALDH1A1MEN1KMT2AGAATSHR | |
| SCHEMBL9494802 | 0.65 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2AGAATSHR | |
| SCHEMBL9494800 | 0.65 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2AGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0494047-A1 | Use of carbazones for the treatment of rheumatoid diseases | CIBA-GEIGY AG (CH) | 1992-07-08 | — | — | EP | claimed |
| US-5177091-A | Rheumatic disorders | CIBA-GEIGY CORPORATION (US) | 1993-01-05 | — | — | US | disclosed |
| EP-0494047-A1 | Use of carbazones for the treatment of rheumatoid diseases | CIBA-GEIGY AG (CH) | 1992-07-08 | — | — | EP | disclosed |