SCHEMBL9493489

SCHEMBL9493489

FC(F)(F)c1cccc2c(Cl)cc(C(Cl)(Cl)Cl)nc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
PARP1 P09874 1/20 0.42
ESR1 P03372 1/20 0.42
CYP2D6 P10635 2/20 0.40
KCNH2 Q12809 7/20 0.40
ADORA2A P29274 5/20 0.40
ADORA1 P30542 5/20 0.40
CYP3A4 P08684 4/20 0.40
HSD11B1 P28845 3/20 0.40
ADORA3 P0DMS8 2/20 0.40
CYP2C19 P33261 2/20 0.40
ADORA2B P29275 1/20 0.40
ABCG2 Q9UNQ0 1/20 0.40
KDM4E B2RXH2 1/20 0.40
NR1I2 O75469 1/20 0.40
LMNA P02545 1/20 0.40
TP53 P04637 1/20 0.40
CYP1A2 P05177 1/20 0.40
HTR1A P08908 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10504531 0.90 L3MBTL1 (0.43) ALDH1A1L3MBTL1PARP1ESR1CYP2D6
SCHEMBL10504620 0.90 ALDH1A1 (0.43) ALDH1A1L3MBTL1PARP1ESR1CYP2D6
SCHEMBL10506369 0.90 CYP3A4 (0.38) ALDH1A1L3MBTL1PARP1ESR1CYP2D6
SCHEMBL1258312 0.90 KCNH2 (0.47) ALDH1A1L3MBTL1PARP1ESR1CYP2D6
SCHEMBL9492503 0.90 CYP3A4 (0.40) ALDH1A1L3MBTL1PARP1CYP2D6CYP3A4
SCHEMBL9493460 0.87 NT5E (0.43) ALDH1A1L3MBTL1ESR1CYP2D6KCNH2
SCHEMBL9493152 0.84 NR4A2 (0.46) ALDH1A1L3MBTL1PARP1CYP3A4KDM4E
SCHEMBL6918746 0.84 ALDH1A1 (0.41) ALDH1A1L3MBTL1PARP1ESR1CYP2D6
SCHEMBL18234113 0.83 ESR1 (0.43) ALDH1A1L3MBTL1PARP1ESR1HSD11B1
SCHEMBL9492598 0.82 ELANE (0.44) L3MBTL1PARP1CYP3A4KDM4ETP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0113432-B1 CHLOROMETHYL QUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE ALKALOIDA VEGYéSZETI GYáR (HU) 1993-03-17 EP claimed
US-4599345-A BACTERICIDES, FUNGICIDES ANTIINFLAMMATORY ALKALOIDE VEGYESZETI GYAR (HU) 1986-07-08 US claimed
EP-0113432-A1 Chloromethyl quinoline derivatives, process for their preparation and their use ALKALOIDA VEGYéSZETI GYáR (HU) 1984-07-18 EP claimed
EP-0113432-B1 CHLOROMETHYL QUINOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE ALKALOIDA VEGYéSZETI GYáR (HU) 1993-03-17 EP disclosed
EP-0111329-B1 FLUOROMETHYL QUINOLINE DERIVATIVES AND THEIR PREPARATION ALKALOIDA VEGYESZETI GYAR (HU) 1989-03-15 EP disclosed
US-4659834-A Process for the preparation of fluoromethyl-quinoline derivatives ALKALOIDA VEGYESZETI GYAR (HU) 1987-04-21 US disclosed
US-4599345-A BACTERICIDES, FUNGICIDES ANTIINFLAMMATORY ALKALOIDE VEGYESZETI GYAR (HU) 1986-07-08 US disclosed
EP-0113432-A1 Chloromethyl quinoline derivatives, process for their preparation and their use ALKALOIDA VEGYéSZETI GYáR (HU) 1984-07-18 EP disclosed
EP-0111329-A1 Fluoromethyl quinoline derivatives and their preparation ALKALOIDA VEGYESZETI GYAR (HU) 1984-06-20 EP disclosed