Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 13/20 | 0.52 |
| ▸ | AGTR2 | P50052 | 13/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9495778 | 0.86 | AGTR1 (0.51) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9703039 | 0.86 | AGTR1 (0.72) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL9499265 | 0.85 | AGTR1 (0.71) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9709788 | 0.78 | AGTR1 (0.48) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9704665 | 0.78 | AGTR1 (0.70) | AGTR1AGTR2 | |
| SCHEMBL9494154 | 0.77 | AGTR1 (0.38) | AGTR1AGTR2 | |
| SCHEMBL6955822 | 0.77 | TP53 (0.41) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL9495708 | 0.77 | AGTR1 (0.68) | AGTR1AGTR2 | |
| SCHEMBL9703709 | 0.77 | AGTR1 (0.73) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9702445 | 0.77 | AGTR1 (0.73) | AGTR1AGTR2PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5236937-A | Treating hypertension, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| EP-0499415-A1 | Pyridine and quinoline derivatives, processes for their manufacture and their use as angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | disclosed |