Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 10/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 8/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9494765 | 0.90 | AGTR1 (0.40) | AGTR1AGTR2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9495733 | 0.90 | AGTR1 (0.40) | AGTR1AGTR2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9494669 | 0.88 | AGTR1 (0.43) | AGTR1AGTR2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9495019 | 0.87 | AGTR1 (0.41) | AGTR1AGTR2ABCG2 | |
| SCHEMBL9499263 | 0.82 | AGTR1 (0.37) | AGTR1AGTR2ABCG2 | |
| SCHEMBL9494917 | 0.82 | AGTR1 (0.37) | AGTR1AGTR2TSHR | |
| SCHEMBL9494452 | 0.81 | AGTR1 (0.65) | AGTR1AGTR2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9499333 | 0.79 | AGTR1 (0.39) | AGTR1AGTR2ABCG2 | |
| SCHEMBL9495030 | 0.75 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL9496620 | 0.75 | AGTR1 (0.36) | AGTR1AGTR2ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5236937-A | Treating hypertension, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |