SCHEMBL9494677

SCHEMBL9494677

COC(=O)c1ccc2c(c1)Oc1ccccc1S2

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.55
TRPA1 O75762 1/20 0.54
KDM4E B2RXH2 3/20 0.46
NPSR1 Q6W5P4 1/20 0.46
KIF11 P52732 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44
HPGD P15428 1/20 0.44
ALOX12 P18054 1/20 0.44
CYP2C19 P33261 1/20 0.44
KMT2A Q03164 1/20 0.44
TSHR P16473 1/20 0.43
TP53 P04637 4/20 0.43
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA7 P43166 1/20 0.42
XDH P47989 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9495867 0.91 ALOX5 (0.58) ALOX5TRPA1KDM4ENPSR1KIF11
SCHEMBL26577416 0.85 TDP1 (0.50) ALOX5TRPA1KDM4ESMN1; SMN2CYP2C9
SCHEMBL9494429 0.85 PABPC1 (0.54) KDM4ESMN1; SMN2KMT2ATP53CA12
SCHEMBL17978231 0.85 CA12 (0.46) ALOX5TRPA1KDM4ESMN1; SMN2CYP1A2
SCHEMBL10513235 0.83 NOX1 (0.55) KDM4ECYP1A2CYP2C9CYP2C19KMT2A
SCHEMBL26114462 0.81 ALOX5 (0.50) ALOX5KMT2ATSHRPOLBTDP1
SCHEMBL9511152 0.81 KDM4E (0.52) KDM4ENPSR1KIF11SMN1; SMN2CYP1A2
SCHEMBL18288011 0.81 ALOX5 (0.68) ALOX5TRPA1KDM4EKIF11SMN1; SMN2
SCHEMBL30572037 0.80 KDM4E (0.46) KDM4ENPSR1SMN1; SMN2KMT2ATSHR
SCHEMBL9496310 0.76 PABPC1 (0.51) KDM4ESMN1; SMN2KMT2ATP53CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250346585-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2025-11-13 US disclosed
WO-2023183405-A2 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2023-09-28 WO disclosed
WO-2023183405-A2 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2023-09-28 WO disclosed
EP-0267794-B1 PROCESS FOR PREPARING POLYOLEFINS Nippon Petrochemicals Co., Ltd. (JP) 1993-05-05 EP disclosed
EP-0267794-A2 Process for preparing polyolefins Nippon Petrochemicals Co., Ltd. (JP) 1988-05-18 EP disclosed
EP-0052471-B1 PROCESS AND CATALYST FOR POLYMERIZATION OF OLEFINS Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1985-09-18 EP disclosed
US-4526941-A Contacting alpha olefin with catalyst comprising organomagnesium compound, titanium compound, nitrogen or sulfur heterocyclic compound, slurry component and organometallic component ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1985-07-02 US disclosed
US-4525555-A TITANIUM COMPOUND SUPPORTED ON SOLID REACTION PRODUCT OF MAGNESIUM HALIDE, SILOXANES, ORGANIC COMPOUNDS NIPPON OIL COMPANY, LIMITED (JP) 1985-06-25 US disclosed
EP-0052471-A1 Process and catalyst for polymerization of olefins Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1982-05-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250346585-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS C5, C1S, C9 ALOX5 193/4885TRPA1 2950/4885KDM4E 4647/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.