Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 12/20 | 0.65 |
| ▸ | AGTR2 | P50052 | 10/20 | 0.65 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9494452 | 0.91 | AGTR1 (0.65) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9495741 | 0.90 | AGTR1 (0.65) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9499344 | 0.87 | AGTR1 (0.47) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9496626 | 0.83 | AGTR1 (0.62) | AGTR1AGTR2 | |
| SCHEMBL9454840 | 0.83 | AGTR1 (0.64) | AGTR1AGTR2 | |
| SCHEMBL9494926 | 0.82 | AGTR1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL9494765 | 0.80 | AGTR1 (0.40) | AGTR1AGTR2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9495030 | 0.80 | AGTR1 (0.47) | AGTR1AGTR2PDE4APDE4BPDE4C | |
| SCHEMBL9499272 | 0.77 | AGTR1 (0.62) | AGTR1AGTR2 | |
| SCHEMBL9494669 | 0.76 | AGTR1 (0.43) | AGTR1AGTR2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5236937-A | Treating hypertension, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| EP-0499415-A1 | Pyridine and quinoline derivatives, processes for their manufacture and their use as angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | disclosed |