Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 9/20 | 0.62 |
| ▸ | AGTR2 | P50052 | 8/20 | 0.62 |
| ▸ | USP1 | O94782 | 1/20 | 0.36 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9496626 | 0.90 | AGTR1 (0.62) | AGTR1AGTR2USP1WDR48 | |
| SCHEMBL9494062 | 0.86 | AGTR1 (0.66) | AGTR1AGTR2 | |
| SCHEMBL9494452 | 0.83 | AGTR1 (0.65) | AGTR1AGTR2 | |
| SCHEMBL9495030 | 0.81 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL9499263 | 0.79 | AGTR1 (0.37) | AGTR1AGTR2 | |
| SCHEMBL9494926 | 0.78 | AGTR1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL9494775 | 0.77 | AGTR1 (0.65) | AGTR1AGTR2 | |
| SCHEMBL9495741 | 0.77 | AGTR1 (0.65) | AGTR1AGTR2 | |
| SCHEMBL9454713 | 0.77 | AGTR1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL9454802 | 0.76 | AGTR1 (0.42) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5236937-A | Treating hypertension, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| EP-0499415-A1 | Pyridine and quinoline derivatives, processes for their manufacture and their use as angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | disclosed |