SCHEMBL9495647

SCHEMBL9495647

CCc1ccoc1[Si](C)(C)C

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.33
ALOX5 P09917 1/20 0.32
GABRA1 P14867 2/20 0.31
GABRB2 P47870 2/20 0.31
CTRC Q99895 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9482555 0.70 TBXAS1 (0.33)
SCHEMBL1608031 0.70
SCHEMBL256685 0.70
SCHEMBL9628732 0.70
SCHEMBL19689261 0.70
SCHEMBL13320157 0.66 KDM4E (0.35) GABRA1GABRB2CTRC
SCHEMBL14388909 0.65
SCHEMBL12188715 0.65 KDM4E (0.39) ALOX5GABRA1GABRB2CTRC
SCHEMBL12948196 0.65 GABRA1 (0.34) ALOX5GABRA1GABRB2
SCHEMBL16382260 0.65 KDM4E (0.54) HSD17B10ALOX5GABRA1GABRB2CTRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0525033-A4 4-(OXYGEN, SULFUR OR NITROGEN SUBSTITUTED)-METHYL 5-HYDROXY-2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS 1993-03-10 EP disclosed