Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.59 |
| ▸ | EDNRA | P25101 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | OXTR | P30559 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045764 | 1.00 | EDNRB (0.59) | EDNRBEDNRAKDM4ERXFP1MEN1 | |
| SCHEMBL9045149 | 0.90 | NPSR1 (0.51) | EDNRBEDNRAKDM4ERXFP1MEN1 | |
| SCHEMBL9043560 | 0.87 | EDNRA (0.59) | EDNRBEDNRAKDM4ERXFP1MEN1 | |
| SCHEMBL9047067 | 0.87 | EDNRB (0.59) | EDNRBEDNRAKDM4ERXFP1MEN1 | |
| SCHEMBL9046709 | 0.87 | ALDH1A1 (0.60) | EDNRBEDNRAMEN1KMT2AALDH1A1 | |
| SCHEMBL9045084 | 0.86 | EDNRA (0.70) | EDNRBEDNRAMEN1KMT2AALDH1A1 | |
| SCHEMBL9046070 | 0.86 | EDNRB (0.53) | EDNRBEDNRAMEN1KMT2AALDH1A1 | |
| SCHEMBL9045067 | 0.86 | EDNRA (0.70) | EDNRBEDNRAMEN1KMT2AALDH1A1 | |
| SCHEMBL9046378 | 0.85 | EDNRA (0.57) | EDNRBEDNRAMEN1KMT2AALDH1A1 | |
| SCHEMBL9046792 | 0.84 | KDM1A (0.56) | EDNRBEDNRAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |