Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | EDNRA | P25101 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | EDNRB | P24530 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045052 | 0.94 | MEN1 (0.55) | EDNRAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9495682 | 0.90 | EDNRB (0.59) | EDNRAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9046709 | 0.90 | ALDH1A1 (0.60) | EDNRAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9045764 | 0.90 | EDNRB (0.59) | EDNRAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9045181 | 0.87 | EDNRA (0.59) | EDNRAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9046700 | 0.87 | EDNRA (0.49) | EDNRAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9047567 | 0.86 | EDNRA (0.51) | EDNRAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9493604 | 0.86 | EDNRA (0.51) | EDNRAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6785011 | 0.86 | EDNRA (0.67) | EDNRAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9044998 | 0.84 | PTGDR2 (0.52) | EDNRAMEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |