Acetone

Acetone

SCHEMBL9496469

CC(C)=O.COc1c2ccc-2c1OC

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
KDM4E B2RXH2 4/20 0.40
ALDH1A1 P00352 3/20 0.40
HSD17B10 Q99714 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
IDO1 P14902 1/20 0.39
MAPT P10636 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
MAPK1 P28482 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ABCB11 O95342 1/20 0.37
CES2 O00748 1/20 0.37
CES1 P23141 1/20 0.37
GAA P10253 1/20 0.36
HTT P42858 1/20 0.36
HPGD P15428 1/20 0.36
ERN1 O75460 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL2455133 0.92 KDM4E (0.43) HDAC4HDAC2HDAC8KDM4EALDH1A1
Acetic Acid Methyl Ester SCHEMBL27436310 0.90 ALDH1A1 (0.50) HDAC4HDAC2HDAC8KDM4EALDH1A1
SCHEMBL6167202 0.90 KDM4E (0.42) HDAC4HDAC2HDAC8KDM4EALDH1A1
SCHEMBL7196023 0.82 HDAC4 (0.42) HDAC4HDAC2HDAC8KDM4EALDH1A1
Acetone SCHEMBL28408688 0.81 LMNA (0.41) KDM4EALDH1A1HSD17B10MAPTTDP1
SCHEMBL7428480 0.80 HDAC4 (0.41) HDAC4HDAC2HDAC8KDM4EALDH1A1
Bromoacetic Acid SCHEMBL29061257 0.79 TSHR (0.43) HDAC4HDAC2HDAC8KDM4EALDH1A1
SCHEMBL7180352 0.76 HDAC4 (0.39) HDAC4HDAC2HDAC8KDM4EALDH1A1
Acetic Acid SCHEMBL4701506 0.74 LMNA (0.40) KDM4EALDH1A1HSD17B10MAPTTDP1
SCHEMBL642228 0.72 HDAC4 (0.58) HDAC4HDAC2HDAC8KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0350069-B1 METHOD FOR OXIDIZING UNSATURATED AROMATIC COMPOUNDS NIPPON PETROCHEMICALS COMPANY, LIMITED (JP) 1993-03-17 EP disclosed