Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ether SCHEMBL4526542 | 0.90 | ALDH1A1 (0.33) | ALDH1A1 | |
| Ether SCHEMBL9009598 | 0.89 | ALDH1A1 (0.37) | ALDH1A1 | |
| Ether SCHEMBL40006 | 0.89 | — | — | |
| Ether SCHEMBL6535103 | 0.89 | ALDH1A1 (0.37) | ALDH1A1 | |
| Ether SCHEMBL28855718 | 0.89 | ALDH1A1 (0.37) | ALDH1A1 | |
| Ether SCHEMBL23704984 | 0.86 | ALDH1A1 (0.35) | ALDH1A1 | |
| Ether SCHEMBL16446730 | 0.86 | ALDH1A1 (0.35) | ALDH1A1 | |
| Ether SCHEMBL7988554 | 0.86 | — | — | |
| Ether SCHEMBL4526541 | 0.83 | ALDH1A1 (0.33) | ALDH1A1 | |
| Ether SCHEMBL4725961 | 0.83 | ALDH1A1 (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208223-A | Enzyme inhibitors | AMERICAN CYANAMID COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| US-5144045-A | Treatment of inflammatory related disorders | AMERICAN CYANAMID COMPANY (US) | 1992-09-01 | — | — | US | disclosed |