Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 2/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.37 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29563815 | 0.90 | TDP1 (0.52) | LMNATDP1KMT2AMEN1THRB | |
| SCHEMBL40458 | 0.90 | TDP1 (0.52) | LMNATDP1KMT2AMEN1THRB | |
| Diethylamine SCHEMBL28827470 | 0.89 | LMNA (0.49) | LMNATDP1KMT2AMEN1THRB | |
| SCHEMBL30293806 | 0.88 | TDP1 (0.50) | LMNATDP1KMT2AMEN1THRB | |
| Water SCHEMBL8176347 | 0.88 | TDP1 (0.50) | LMNATDP1KMT2AMEN1THRB | |
| SCHEMBL549939 | 0.88 | TDP1 (0.50) | LMNATDP1KMT2AMEN1THRB | |
| SCHEMBL1302666 | 0.88 | TDP1 (0.50) | LMNATDP1KMT2AMEN1THRB | |
| SCHEMBL2986619 | 0.88 | TDP1 (0.50) | LMNATDP1KMT2AMEN1THRB | |
| Alcohol SCHEMBL10347133 | 0.87 | ALDH1A1 (0.36) | LMNATDP1KMT2AMEN1THRB | |
| Water SCHEMBL1403479 | 0.86 | TDP1 (0.48) | LMNATDP1KMT2AMEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229250-A | Photoresist with acrylic acid and dimethylaminoethyl (meth) acrylate polymer | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-07-20 | — | — | US | disclosed |
| US-5187059-A | From monomers of acrylic acid and at least N,N-diemtyl-or N,N-diethylaminoethyl methacrlate | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-02-16 | — | — | US | disclosed |
| US-5011898-A | Derived from acrylic acid, protonated dialkylaminoethyl acrylate photographic gelatin replacements or extenders | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-04-30 | — | — | US | disclosed |
| US-4749762-A | SELECTIVE BASIC HYDROLYSIS OF ACRYLATES TO SALTS; FREE OR BETAINE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-06-07 | — | — | US | disclosed |