Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 7/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11145536 | 0.99 | CCKBR (0.57) | CCKBROPRD1OPRK1OPRM1 | |
| SCHEMBL7336834 | 0.88 | CCKBR (0.62) | CCKBROPRD1OPRK1OPRM1 | |
| SCHEMBL10969949 | 0.87 | CCKBR (0.49) | CCKBROPRD1OPRK1OPRM1 | |
| SCHEMBL7347898 | 0.85 | CCKBR (0.56) | CCKBROPRD1OPRK1OPRM1 | |
| SCHEMBL10963853 | 0.84 | OPRK1 (0.54) | CCKBROPRD1OPRK1OPRM1 | |
| Hydrochloric Acid SCHEMBL10966522 | 0.83 | OPRK1 (0.53) | CCKBROPRD1OPRK1OPRM1 | |
| SCHEMBL10732045 | 0.80 | OPRK1 (0.50) | CCKBROPRD1OPRK1OPRM1 | |
| SCHEMBL10737461 | 0.80 | CCKBR (0.43) | CCKBROPRD1OPRK1OPRM1 | |
| Hydrochloric Acid SCHEMBL10729969 | 0.79 | OPRK1 (0.49) | CCKBROPRD1OPRK1OPRM1 | |
| Hydrochloric Acid SCHEMBL10733249 | 0.78 | OPRK1 (0.38) | CCKBROPRD1OPRK1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166356-B1 | 2-SUBSTITUTED-AMINOMETHYL-1,4-BENZODIAZEPINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1993-09-01 | — | — | EP | disclosed |
| US-5206238-A | Cholecystokinin antagonists | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0486271-A2 | Cholecystokinin antagonists for treating neurological disorders | MERCK & CO. INC. (US) | 1992-05-20 | — | — | EP | disclosed |
| US-4724237-A | GASTROINTESTINAL, CENTRAL NERVOUS, AND APPETITE DISORDERS | MERCK & CO., INC. (US) | 1988-02-09 | — | — | US | disclosed |
| EP-0166356-A2 | 2-Substituted-aminomethyl-1,4-benzodiazepines, process for their preparation and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-02 | — | — | EP | disclosed |