Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.76 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.54 |
| ▸ | HTR1B | P28222 | 1/20 | 0.54 |
| ▸ | HTR1F | P30939 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.52 |
| ▸ | TUBB | P07437 | 1/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.52 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.52 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.52 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5955783 | 0.87 | HTR6 (0.58) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL1486947 | 0.86 | HTR6 (1.00) | HTR6HTR1ADRD2DRD4HTR1D | |
| Hydrochloric Acid SCHEMBL1486945 | 0.85 | HTR6 (0.97) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL5955805 | 0.84 | HTR6 (0.55) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL7380594 | 0.84 | KDM4E (0.60) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL3280964 | 0.82 | EGFR (0.57) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL28156846 | 0.82 | KDM4E (0.60) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL5495499 | 0.82 | HTR6 (0.66) | HTR6HTR1ADRD2DRD4HTR1D | |
| SCHEMBL2003146 | 0.82 | KDM4E (0.72) | HTR6KDM4EALDH1A1FOLH1MCL1 | |
| SCHEMBL3276728 | 0.81 | EGFR (0.66) | HTR6HTR1ADRD2DRD4HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233413-B1 | 3-(2-AMINOETHYL)INDOLE AND -INDOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1993-05-05 | — | — | EP | disclosed |
| US-4980368-A | CEREBRALVASCULAR DISORDERS; ANTIHYPOXIA AGENTS; COGNITION ACTIVATORS; SENILITY | BEECHAM-WUELFING GMBH & CO. KG (DE) | 1990-12-25 | — | — | US | disclosed |
| EP-0233413-A2 | 3-(2-Aminoethyl)indole and -indoline derivatives, processes for their preparation and pharmaceutical compositions containing them | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1987-08-26 | — | — | EP | disclosed |