Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.72 |
| ▸ | HTR6 | P50406 | 1/20 | 0.66 |
| ▸ | MCL1 | Q07820 | 13/20 | 0.63 |
| ▸ | ALB | P02768 | 1/20 | 0.56 |
| ▸ | BCL2 | P10415 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5495499 | 0.87 | HTR6 (0.66) | KDM4EALDH1A1FOLH1HTR6MCL1 | |
| SCHEMBL2002751 | 0.87 | FOLH1 (0.71) | KDM4EALDH1A1FOLH1MCL1ALB | |
| SCHEMBL5955774 | 0.85 | ALDH1A1 (0.74) | KDM4EALDH1A1FOLH1MCL1ALB | |
| SCHEMBL29514964 | 0.84 | FOLH1 (1.00) | KDM4EALDH1A1FOLH1MCL1ALB | |
| SCHEMBL9188195 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1FOLH1MCL1 | |
| SCHEMBL223344 | 0.84 | FOLH1 (1.00) | KDM4EALDH1A1FOLH1MCL1ALB | |
| SCHEMBL29432490 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1FOLH1MCL1 | |
| SCHEMBL13701155 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1FOLH1MCL1ALB | |
| SCHEMBL9499798 | 0.82 | HTR6 (0.76) | KDM4EALDH1A1FOLH1HTR6MCL1 | |
| SCHEMBL3205801 | 0.81 | KDM4E (0.69) | KDM4EALDH1A1FOLH1MCL1ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
| US-7429611-B2 | Indole inhibitors of 15-lipoxygenase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429611-B2 | Indole inhibitors of 15-lipoxygenase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2007017546-A3 | METHOD OF OBTAINING TRYPTAMINE DERIVATIVES | RAGACTIVES SL (ES) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007017546-A2 | METHOD OF OBTAINING TRYPTAMINE DERIVATIVES | RAGACTIVES, S.L. (ES) | 2007-02-15 | — | — | WO | disclosed |
| EP-1709040-A2 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF SRC FAMILY PROTEIN KINASE | Sirenade Pharmaceuticals AG (DE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2006034391-A2 | INDOLE INHIBITORS OF 15-LIPOXYGENASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-03-30 | — | — | WO | disclosed |
| US-20060063822-A1 | Indole inhibitors of 15-lipoxygenase | BRISTOL-MYERS SQUIBB COMPANY | 2006-03-23 | — | — | US | disclosed |
| WO-2005068458-A2 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF SRC FAMILY PROTEIN KINASE | SIRENADE PHARMACEUTICALS AG (DE) | 2005-07-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063822-A1 | Indole inhibitors of 15-lipoxygenase | ALOX15, ALOX5, ALOX15B | KDM4E 1628/4885ALDH1A1 612/4885FOLH1 4220/4885 |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | FAAH, FAAH2, AANAT | KDM4E 2232/4885ALDH1A1 178/4885FOLH1 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.