Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9501978 | 0.87 | MAPT (0.56) | MAPTLMNAGAARAB9APTGDR2 | |
| SCHEMBL9499536 | 0.83 | TRPV1 (0.57) | MAPTLMNARAB9AHDAC1 | |
| SCHEMBL10823192 | 0.81 | IDO1 (0.50) | MAPTLMNAKDR | |
| SCHEMBL7164864 | 0.81 | NPC1 (0.52) | MAPTLMNAGAARAB9AMEN1 | |
| SCHEMBL10184841 | 0.79 | KDR (0.59) | MAPTLMNAGAARAB9APTGDR2 | |
| SCHEMBL13988583 | 0.79 | PTGDR2 (0.57) | MAPTLMNAGAARAB9APTGDR2 | |
| SCHEMBL9500932 | 0.78 | RAB9A (0.58) | MAPTLMNAGAARAB9AMEN1 | |
| SCHEMBL11793308 | 0.78 | KDR (0.68) | MAPTLMNAGAARAB9AKDR | |
| SCHEMBL9499648 | 0.77 | NPC1 (0.59) | MAPTLMNAGAARAB9AMEN1 | |
| SCHEMBL3973967 | 0.76 | KDR (0.66) | MAPTLMNAGAARAB9APTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273444-B1 | USE OF CARBOXAMIDE COMPOUNDS FOR THE PREPARATION OF A MEDICAMENT FOR TREATING HYPERLIPIDEMIA | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1993-05-05 | — | — | EP | claimed |
| US-5081112-A | Administering an aryl phosphonate carboxamide | OTSUKA PHARMACEUTICAL FACTORY INC. (JP) | 1992-01-14 | — | — | US | claimed |
| EP-0273444-A2 | Use of carboxamide compounds for the preparation of a medicament for treating hyperlipidemia | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1988-07-06 | — | — | EP | claimed |
| EP-0273444-B1 | USE OF CARBOXAMIDE COMPOUNDS FOR THE PREPARATION OF A MEDICAMENT FOR TREATING HYPERLIPIDEMIA | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1993-05-05 | — | — | EP | disclosed |
| US-5081112-A | Administering an aryl phosphonate carboxamide | OTSUKA PHARMACEUTICAL FACTORY INC. (JP) | 1992-01-14 | — | — | US | disclosed |
| EP-0273444-A2 | Use of carboxamide compounds for the preparation of a medicament for treating hyperlipidemia | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1988-07-06 | — | — | EP | disclosed |