Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.66 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.62 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.60 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | XBP1 | P17861 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11793308 | 0.90 | KDR (0.68) | KDRTMPRSS4MAPTLMNAGAA | |
| SCHEMBL3977997 | 0.87 | KDR (0.64) | KDRTRPV1TMPRSS4MAPTLMNA | |
| SCHEMBL6055167 | 0.87 | LMNA (0.70) | KDRTRPV1TMPRSS4MAPTLMNA | |
| SCHEMBL281864 | 0.85 | KDR (0.85) | KDRTRPV1PDK1 | |
| SCHEMBL28389908 | 0.85 | KDR (0.61) | KDRTRPV1TMPRSS4MAPTLMNA | |
| SCHEMBL5631971 | 0.85 | LMNA (0.70) | KDRTRPV1TMPRSS4MAPTLMNA | |
| SCHEMBL4249329 | 0.84 | RAB9A (0.71) | KDRTMPRSS4MAPTLMNAGAA | |
| SCHEMBL10184841 | 0.84 | KDR (0.59) | KDRTRPV1TMPRSS4MAPTLMNA | |
| SCHEMBL6365067 | 0.83 | MAPT (0.64) | KDRTRPV1MAPTLMNAGAA | |
| SCHEMBL10656168 | 0.82 | KDR (0.61) | KDRTRPV1TMPRSS4MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009054004-A2 | PROCESS FOR THE PREPARATION OF SORAFENIB | NATCO PHARMA LIMITED (IN) | 2009-04-30 | — | — | WO | disclosed |