Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.68 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7158810 | 0.89 | SLC6A4 (0.73) | SLC6A4HRH3SLC6A2SLC6A9HTR2A | |
| SCHEMBL5270870 | 0.86 | SLC6A4 (0.70) | SLC6A4HRH3SLC6A2SLC6A9HTR2A | |
| SCHEMBL685134 | 0.86 | SLC6A4 (0.70) | SLC6A4HRH3SLC6A2SLC6A9HTR2A | |
| SCHEMBL10913184 | 0.85 | SLC6A4 (0.68) | SLC6A4HRH3SLC6A2SLC6A9 | |
| SCHEMBL4785426 | 0.85 | SLC6A4 (0.68) | SLC6A4HRH3SLC6A2SLC6A9HTR2A | |
| SCHEMBL27722798 | 0.83 | SLC6A4 (0.53) | SLC6A4HRH3SLC6A2HTR2AHRH1 | |
| SCHEMBL9499401 | 0.82 | SLC6A4 (0.65) | SLC6A4HRH3SLC6A2SLC6A9 | |
| SCHEMBL9501066 | 0.82 | SLC6A4 (0.61) | SLC6A4HRH3SLC6A9 | |
| SCHEMBL15618532 | 0.82 | SLC6A4 (0.57) | SLC6A4HRH3SLC6A2SLC6A9HTR2A | |
| SCHEMBL11239618 | 0.82 | SLC6A4 (0.68) | SLC6A4HRH3SLC6A2SLC6A9HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014046544-A1 | SUBSTITUTED 3-HETEROARYLOXY-3-(HETERO)ARYL-PROPYLAMINES AS SEROTONIN TRANSPORTER AND SEROTONIN HT2C RECEPTOR MODULATORS | AAPA B.V. (NL) | 2014-03-27 | — | — | WO | disclosed |
| US-5238959-A | For inhibiting serotonin uptake, antidepressant, suppression of alcoholism and obesity | ELI LILLY AND COMPANY (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0336753-B1 | IMPROVEMENTS IN OR RELATING TO PROPANAMINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1992-07-08 | — | — | EP | disclosed |
| EP-0336753-A1 | Improvements in or relating to propanamine derivatives | ELI LILLY AND COMPANY (US) | 1989-10-11 | — | — | EP | disclosed |
| US-4296126-A | 3-Aryloxy-3-aryl-propaneamines and their method of use | ROUSSEL UCLAF (FR) | 1981-10-20 | — | — | US | disclosed |