Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL700909 | 1.00 | TSHR (0.42) | TSHRTP53CA1CA2CA9 | |
| Bicarbonate SCHEMBL5385074 | 0.96 | TSHR (0.40) | TSHRTP53CA1CA2CA9 | |
| Benzene SCHEMBL28129217 | 0.93 | TSHR (0.38) | TSHRTP53CA1CA2CA9 | |
| Bicarbonate SCHEMBL4239205 | 0.87 | TSHR (0.35) | TSHRTP53HCAR2 | |
| Tert-Butyl Hydroperoxide SCHEMBL28766180 | 0.85 | ALDH1A1 (0.50) | TSHRTP53HCAR2ALDH1A1 | |
| SCHEMBL126090 | 0.83 | — | — | |
| Bicarbonate SCHEMBL736567 | 0.81 | ALDH1A1 (0.32) | TSHRFFAR3ALDH1A1 | |
| SCHEMBL29728818 | 0.80 | TSHR (0.37) | TSHRALDH1A1 | |
| Benzene SCHEMBL864531 | 0.80 | TSHR (0.32) | TSHRALDH1A1 | |
| SCHEMBL11760806 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3858 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250353967-A1 | CURABLE SILOXANE RESIN COMPOSITION AND FILM INCLUDING THE SAME | KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2025-11-20 | — | — | US | claimed |
| US-20250270349-A1 | METHOD FOR MANUFACTURING FLUOROELASTOMERS | SOLVAY SPECIALTY POLYMERS ITALY S.P.A. (IT) | 2025-08-28 | — | — | US | claimed |
| US-12331164-B2 | Curable siloxane resin composition | KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2025-06-17 | — | — | US | claimed |
| US-20240181430-A1 | POROUS SORPTIVE SOLID PHASE MICROEXTRACTION DEVICES AND PREPARATION THEREOF | MEMORIAL UNIVERSITY OF NEWFOUNDLAND (CA) | 2024-06-06 | — | — | US | claimed |
| EP-4294559-A1 | POROUS SORPTIVE SOLID PHASE MICROEXTRACTION DEVICES AND PREPARATION THEREOF | Memorial University of Newfoundland (CA) | 2023-12-27 | — | — | EP | claimed |
| WO-2023240543-A1 | BINDER, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 宁德时代新能源科技股份有限公司 | 2023-12-21 | — | — | WO | claimed |
| EP-4259667-A1 | METHOD FOR MANUFACTURING FLUOROELASTOMERS | Solvay Specialty Polymers Italy S.p.A. (IT) | 2023-10-18 | — | — | EP | claimed |
| WO-2023140097-A1 | METHOD FOR MANUFACTURING MODIFIED ALIPHATIC OR ALIPHATIC AROMATIC THERMOPLASTIC POLYESTER RESIN | 株式会社カネカ | 2023-07-27 | — | — | WO | claimed |
| WO-2023140096-A1 | MODIFIED ALIPHATIC POLYESTER-BASED RESIN AND COMPOSITION OR MOLDED BODY THEREOF | 株式会社カネカ | 2023-07-27 | — | — | WO | claimed |
| US-20230078587-A1 | CURABLE SILOXANE RESIN COMPOSITION | KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2023-03-16 | — | — | US | claimed |
| US-4552682-A | Peroxide composition containing phenolic antioxidant | PPG INDUSTRIES, INC. (US) | 1985-11-12 | — | — | US | claimed |
| EP-0114080-A1 | Polymerizable liquid composition adapted to produce polymers having outstanding optical and mechanical properties, polymers and articles obtained with said composition | ENICHEM SYNTHESIS S.p.A. (IT) | 1984-07-25 | — | — | EP | claimed |
| US-4396527-A | Aqueous emulsions of organic peroxides | NIPPON OIL AND FATS CO., LTD. (JP) | 1983-08-02 | — | — | US | claimed |
| US-4366290-A | UNSATURATED PEROXYCARBONATE | NIPPON OIL AND FATS CO., LTD. (JP) | 1982-12-28 | — | — | US | claimed |
| US-4039595-A | Copolymers of ethylene and hexafluoropropene | PENNWALT CORPORATION (US) | 1977-08-02 | — | — | US | claimed |
| US-4008175-A | Organic acid anhydride-peroxydicarbonate composition | PPG INDUSTRIES, INC. (US) | 1977-02-15 | — | — | US | claimed |
| US-3966787-A | Process for the preparation of granular or pulverulent organic peroxides | AKZO N.V. (NL) | 1976-06-29 | — | — | US | claimed |
| US-3966414-A | FREE-RADICAL SENSITIVE DYE, PEROXIDE | BIO-MEDICAL SCIENCES, INC. (US) | 1976-06-29 | — | — | US | claimed |
| US-3960825-A | TOUGHNESS, HEAT RESISTANCE, FLEXIBILITY, NO NELASTIC | PENNWALT CORPORATION (US) | 1976-06-01 | — | — | US | claimed |
| US-3945958-A | WATER-SOLUBLE CELLULOSE ETHERS, VISCOSITY | SHINETSU CHEMICAL COMPANY (JA) | 1976-03-23 | — | — | US | claimed |