Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL95011 | 1.00 | TSHR (0.42) | TSHRTP53CA1CA2CA9 | |
| Bicarbonate SCHEMBL5385074 | 0.96 | TSHR (0.40) | TSHRTP53CA1CA2CA9 | |
| Benzene SCHEMBL28129217 | 0.93 | TSHR (0.38) | TSHRTP53CA1CA2CA9 | |
| Bicarbonate SCHEMBL4239205 | 0.87 | TSHR (0.35) | TSHRTP53HCAR2 | |
| Tert-Butyl Hydroperoxide SCHEMBL28766180 | 0.85 | ALDH1A1 (0.50) | TSHRTP53HCAR2ALDH1A1 | |
| SCHEMBL126090 | 0.83 | — | — | |
| Bicarbonate SCHEMBL736567 | 0.81 | ALDH1A1 (0.32) | TSHRFFAR3ALDH1A1 | |
| SCHEMBL29728818 | 0.80 | TSHR (0.37) | TSHRALDH1A1 | |
| Benzene SCHEMBL864531 | 0.80 | TSHR (0.32) | TSHRALDH1A1 | |
| SCHEMBL11760806 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 825 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12595362-B2 | Polypropylene resin composition with excellent flame retardancy and formability | HYUNDAI MOTOR COMPANY (KR) | 2026-04-07 | — | — | US | claimed |
| EP-4536719-A1 | NON-LINEAR VINYLIDENE FLUORIDE COPOLYMERS | Arkema, Inc. (US) | 2025-04-16 | — | — | EP | claimed |
| US-20240076483-A1 | Polypropylene Resin Composition with Excellent Flame Retardancy and Formability | HYUNDAI MOTOR COMPANY (KR) | 2024-03-07 | — | — | US | claimed |
| CN-117624777-A | Polypropylene resin composition having excellent flame retardancy and moldability | 现代自动车株式会社 | 2024-03-01 | — | — | CN | claimed |
| CN-117327389-A | High-temperature-resistant expandable framework/PMI composite material and preparation method thereof | 浙江中科恒泰新材料科技有限公司 | 2024-01-02 | — | — | CN | claimed |
| WO-2023239537-A1 | NON-LINEAR VINYLIDENE FLUORIDE COPOLYMERS | ARKEMA INC. (US) | 2023-12-14 | — | — | WO | claimed |
| CN-116120691-B | Polymethacrylimide foam and preparation method thereof | 湖南羽银科技有限责任公司 | 2023-10-17 | — | — | CN | claimed |
| CN-116648081-A | Plasmon cavity structure coupled quantum dot light emitting diode and preparation method thereof | 西北工业大学 | 2023-08-25 | — | — | CN | claimed |
| CN-116120691-A | Polymethacrylimide foam and preparation method thereof | 湖南羽银科技有限责任公司 | 2023-05-16 | — | — | CN | claimed |
| CN-113321877-B | Recyclable flexible radiation-proof sheet and preparation method thereof | 天津天颐科苑科技有限公司 | 2023-04-07 | — | — | CN | claimed |
| US-4607087-A | POLYMERIZING DIETHYLENE GLYCOL BISALLYL CARBONATE USING DECOMPOSABLE ORGANIC PEROXIDES AS INITIATORS | NIPPON OIL AND FATS COMPANY LTD. (JP) | 1986-08-19 | — | — | US | claimed |
| US-4590248-A | POLYMERIZATION OF BIS(ALLYL CARBONATE)OF DIETHYLENE GLYCOL | NIPPON OIL AND FATS CO., LTD. (JP) | 1986-05-20 | — | — | US | claimed |
| EP-0090627-A2 | Method for producing a plastic lens | NIPPON OIL AND FATS COMPANY, LIMITED (JP) | 1983-10-05 | — | — | EP | claimed |
| US-4405773-A | Hydrophylic contact lenses and methods for making same | SCHERING CORPORATION (US) | 1983-09-20 | — | — | US | claimed |
| US-4268651-A | Two-phase vinyl chloride polymerization | RHONE-POULENC INDUSTRIES (FR) | 1981-05-19 | — | — | US | claimed |
| US-4029619-A | ANTISCALING | SHINETSU CHEMICAL COMPANY (JA) | 1977-06-14 | — | — | US | claimed |
| US-3959235-A | DI-INDOLYL COMPOUNDS | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JA) | 1976-05-25 | — | — | US | claimed |
| US-3956244-A | COPOLYMERIZATION | N L INDUSTRIES, INC. (US) | 1976-05-11 | — | — | US | claimed |
| US-3951925-A | TWO STEP SUSPENSION POLYMERIZATION USING AN OIL SOLUBLE RADICAL INITIATOR | CHISSO CORPORATION (JA) | 1976-04-20 | — | — | US | claimed |
| US-3943132-A | Process for the preparation of hydrazones | PRODUITS CHIMIQUES UGINE KUHLMANN (FR) | 1976-03-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12595362-B2 | Polypropylene resin composition with excellent flame retardancy and formability | PFKFB1, PF4, PFKFB4 | TSHR 1817/4885TP53 2185/4885CA1 2464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.