Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 11/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 12/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 11/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13227810 | 0.75 | NOTUM (0.50) | CACNA1IALOX12CACNA1GCACNA1HNOTUM | |
| SCHEMBL3553533 | 0.74 | ALOX15 (0.43) | CACNA1IALOX12CACNA1GCACNA1HNOTUM | |
| SCHEMBL8202698 | 0.74 | TAAR1 (0.54) | — | |
| SCHEMBL3553536 | 0.74 | ALOX15 (0.43) | CACNA1IALOX12CACNA1GCACNA1HNOTUM | |
| SCHEMBL5870956 | 0.74 | SIRT2 (0.47) | CACNA1ICACNA1GCACNA1HGRM2 | |
| SCHEMBL20879389 | 0.74 | HDAC6 (0.55) | — | |
| SCHEMBL7695554 | 0.74 | SIRT2 (0.51) | ALOX12NOTUMBRD4 | |
| SCHEMBL17846769 | 0.74 | CACNA1I (0.44) | CACNA1ICACNA1GCACNA1H | |
| SCHEMBL6684665 | 0.73 | PRCP (0.45) | ALOX12NOTUMROCK1DRD2DRD4 | |
| SCHEMBL26091678 | 0.72 | CACNA1I (0.41) | CACNA1ICACNA1GCACNA1HBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5214058-A | Acetylcholinesterase inhibitors, treatment of senile dementia | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0471296-A1 | 1-(Pyridinylalkyl)-1H-indoles, indolines and related analogs | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-02-19 | — | — | EP | disclosed |