Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.49 |
| ▸ | RARB | P10826 | 9/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RARA | P10276 | 2/20 | 0.48 |
| ▸ | RARG | P13631 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | TACR2 | P21452 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2094335 | 0.95 | HSD11B1 (0.47) | HSD11B1RARBHSD17B10TSHRRARA | |
| SCHEMBL6745029 | 0.82 | RARB (0.58) | HSD11B1RARBHSD17B10TSHRRARA | |
| SCHEMBL28364847 | 0.81 | BCL2 (0.53) | HSD11B1RARBHSD17B10TSHRRARA | |
| SCHEMBL9658418 | 0.81 | HSD11B1 (0.54) | HSD11B1RARBHSD17B10TSHRRARA | |
| SCHEMBL27958067 | 0.80 | HSD17B10 (0.61) | RARBHSD17B10TSHRRARARARG | |
| SCHEMBL6747872 | 0.80 | HSD17B10 (0.61) | RARBHSD17B10TSHRRARARARG | |
| SCHEMBL5252629 | 0.80 | LPL (0.56) | CYP3A4PTGS2LPLLIPG | |
| SCHEMBL1817958 | 0.80 | TAAR1 (0.63) | HSD11B1RARBHSD17B10TSHRRARA | |
| Bromide SCHEMBL28347006 | 0.80 | HSD11B1 (0.53) | HSD11B1RARBHSD17B10TSHRRARA | |
| SCHEMBL1203500 | 0.80 | HSD11B1 (0.69) | HSD11B1RARBHSD17B10TSHRRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273444-B1 | USE OF CARBOXAMIDE COMPOUNDS FOR THE PREPARATION OF A MEDICAMENT FOR TREATING HYPERLIPIDEMIA | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1993-05-05 | — | — | EP | disclosed |
| US-5081112-A | Administering an aryl phosphonate carboxamide | OTSUKA PHARMACEUTICAL FACTORY INC. (JP) | 1992-01-14 | — | — | US | disclosed |
| EP-0273444-A2 | Use of carboxamide compounds for the preparation of a medicament for treating hyperlipidemia | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1988-07-06 | — | — | EP | disclosed |