Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20825056 | 0.80 | SIGMAR1 (0.45) | NOTUMHTTSMN1; SMN2SIGMAR1SRD5A1 | |
| SCHEMBL27821528 | 0.80 | NOTUM (0.42) | NOTUMHTTSMN1; SMN2SIGMAR1SRD5A1 | |
| SCHEMBL15079041 | 0.78 | SRD5A1 (0.40) | MTNR1AMTNR1BSMN1; SMN2SRD5A1SRD5A2 | |
| SCHEMBL20192293 | 0.78 | NPC1 (0.48) | MTNR1AMTNR1BSMN1; SMN2POLBNPC1 | |
| SCHEMBL15079053 | 0.78 | HSP90AA1 (0.43) | SMN1; SMN2SIGMAR1POLBSRD5A1SRD5A2 | |
| SCHEMBL15059721 | 0.77 | NR1H4 (0.52) | SIGMAR1NPC1RAB9ACYP2C19 | |
| SCHEMBL20824984 | 0.76 | SIGMAR1 (0.43) | MTNR1AMTNR1BHTTSMN1; SMN2SIGMAR1 | |
| SCHEMBL16263332 | 0.76 | SIGMAR1 (0.46) | HTTSMN1; SMN2SIGMAR1KDM4CNPC1 | |
| SCHEMBL2674626 | 0.76 | SIGMAR1 (0.43) | NOTUMHTTSIGMAR1SRD5A1SRD5A2 | |
| SCHEMBL7401882 | 0.74 | SIGMAR1 (0.45) | NOTUMSIGMAR1SRD5A1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0335375-B1 | ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC COMPOUNDS AND COMPOSITIONS | WARNER-LAMBERT COMPANY (US) | 1993-06-09 | — | — | EP | claimed |
| EP-0335375-A2 | Antihyperlipidemic and antiatherosclerotic compounds and compositions | WARNER-LAMBERT COMPANY (US) | 1989-10-04 | — | — | EP | claimed |
| EP-0335375-B1 | ANTIHYPERLIPIDEMIC AND ANTIATHEROSCLEROTIC COMPOUNDS AND COMPOSITIONS | WARNER-LAMBERT COMPANY (US) | 1993-06-09 | — | — | EP | disclosed |
| EP-0335375-A2 | Antihyperlipidemic and antiatherosclerotic compounds and compositions | WARNER-LAMBERT COMPANY (US) | 1989-10-04 | — | — | EP | disclosed |