Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 9/20 | 0.59 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TACR3 | P29371 | 4/20 | 0.48 |
| ▸ | TACR2 | P21452 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502807 | 0.85 | DHODH (0.64) | DHODHPDE10ATSHRLMNACYP2D6 | |
| SCHEMBL5498214 | 0.82 | PDE10A (0.62) | DHODHPDE10ATSHRLMNACYP2D6 | |
| SCHEMBL9505258 | 0.82 | DHODH (0.69) | DHODHPDE10A | |
| SCHEMBL10559127 | 0.81 | DHODH (0.67) | DHODHPDE10A | |
| SCHEMBL3959255 | 0.79 | TACR3 (0.68) | DHODHPDE10ATSHRLMNACYP2D6 | |
| SCHEMBL14492079 | 0.74 | PDE10A (0.68) | DHODHPDE10ATSHRLMNACYP2D6 | |
| SCHEMBL4234246 | 0.74 | DHODH (0.57) | DHODHPDE10ATSHRLMNACYP2D6 | |
| SCHEMBL4897475 | 0.73 | TACR3 (0.68) | DHODHPDE10ATSHRLMNACYP2D6 | |
| SCHEMBL5496908 | 0.73 | SMN1; SMN2 (0.56) | DHODHPDE10ATSHRLMNATACR3 | |
| SCHEMBL9501979 | 0.73 | DHODH (1.00) | DHODHPDE10ATSHRLMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0305952-B1 | SUBSTITUTED 2-PHENYL-4-QUINOLINE-CARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |
| US-4847381-A | ANTIARTHRITIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0305952-A1 | Substituted 2-phenyl-4-quinoline-carboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1989-03-08 | — | — | EP | disclosed |