Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 19/20 | 0.69 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10559127 | 0.97 | DHODH (0.67) | DHODHPDE10ADHFRALKBH5 | |
| SCHEMBL9501944 | 0.82 | DHODH (0.59) | DHODHPDE10A | |
| SCHEMBL9505314 | 0.81 | DHODH (0.74) | DHODHPDE10ADHFRALKBH5 | |
| SCHEMBL9501970 | 0.81 | DHODH (0.74) | DHODHPDE10ADHFRALKBH5 | |
| SCHEMBL8732559 | 0.76 | DHODH (1.00) | DHODHDHFRALKBH5 | |
| SCHEMBL8792827 | 0.75 | DHODH (0.71) | DHODHPDE10ADHFRALKBH5 | |
| SCHEMBL9502210 | 0.74 | DHODH (1.00) | DHODHPDE10ADHFRALKBH5 | |
| SCHEMBL8792419 | 0.74 | DHODH (1.00) | DHODHDHFRALKBH5 | |
| SCHEMBL5908719 | 0.73 | DHODH (0.95) | DHODHPDE10ADHFRALKBH5 | |
| SCHEMBL29370975 | 0.73 | KMT2A (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0305952-B1 | SUBSTITUTED 2-PHENYL-4-QUINOLINE-CARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |
| US-4847381-A | ANTIARTHRITIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0305952-A1 | Substituted 2-phenyl-4-quinoline-carboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1989-03-08 | — | — | EP | disclosed |