Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 10/20 | 0.64 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | TACR3 | P29371 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498214 | 0.97 | PDE10A (0.62) | DHODHPDE10ATSHRLMNACYP2D6 | |
| SCHEMBL9502242 | 0.86 | DHODH (0.63) | DHODHPOLB | |
| SCHEMBL9501944 | 0.85 | DHODH (0.59) | DHODHPDE10ATSHRLMNACYP2D6 | |
| SCHEMBL9505833 | 0.84 | DHODH (0.50) | DHODHPDE10ATSHRLMNACYP2D6 | |
| SCHEMBL3959255 | 0.83 | TACR3 (0.68) | DHODHPDE10ATSHRLMNACYP2D6 | |
| SCHEMBL5496908 | 0.82 | SMN1; SMN2 (0.56) | DHODHPDE10ATSHRLMNATACR3 | |
| SCHEMBL27583476 | 0.79 | PDE10A (0.60) | DHODHPDE10ATSHRLMNACYP2D6 | |
| SCHEMBL9501979 | 0.77 | DHODH (1.00) | DHODHPDE10ATSHRLMNACYP2D6 | |
| SCHEMBL8792622 | 0.77 | DHODH (0.72) | DHODHPDE10ATSHRLMNACYP2D6 | |
| SCHEMBL4720452 | 0.76 | TACR3 (0.82) | TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0305952-B1 | SUBSTITUTED 2-PHENYL-4-QUINOLINE-CARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1993-06-02 | — | — | EP | claimed |
| EP-0305952-A1 | Substituted 2-phenyl-4-quinoline-carboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1989-03-08 | — | — | EP | claimed |
| JP-1110673-A | — | — | None | — | — | JP | disclosed |
| EP-0305952-B1 | SUBSTITUTED 2-PHENYL-4-QUINOLINE-CARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |
| US-4847381-A | ANTIARTHRITIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| JP-H01110673-A | SUBSTITUTED 2-PHENYL-4-QUINOLINECARBOXYLIC ACID | AMERICAN CYANAMID CO | 1989-04-27 | — | — | JP | disclosed |
| EP-0305952-A1 | Substituted 2-phenyl-4-quinoline-carboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1989-03-08 | — | — | EP | disclosed |