⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27497716 | 1.00 | — | — | |
| SCHEMBL28325898 | 0.73 | — | — | |
| SCHEMBL8091808 | 0.66 | — | — | |
| SCHEMBL8654218 | 0.63 | LMNA (0.30) | — | |
| SCHEMBL441725 | 0.63 | — | — | |
| SCHEMBL25822940 | 0.61 | PIK3CD (0.30) | — | |
| SCHEMBL10738725 | 0.60 | LMNA (0.34) | — | |
| SCHEMBL22833704 | 0.59 | — | — | |
| SCHEMBL13284102 | 0.58 | GABRP (0.31) | — | |
| SCHEMBL2080450 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287340-B1 | NOVEL ACYLATION PROCESS FOR THE SYNTHESIS OF HMG-COA REDUCTASE INHIBITORS | MERCK & CO. INC. (US) | 1993-09-29 | — | — | EP | disclosed |
| EP-0325817-B1 | NOVEL HMG-COA REDUCTASE INHIBITORS | MERCK & CO. INC. (US) | 1993-05-26 | — | — | EP | disclosed |
| EP-0327166-B1 | NOVEL HMG-COA REDUCTASE INHIBITORS | Merck & Co., Inc. (US) | 1992-12-30 | — | — | EP | disclosed |
| EP-0327165-A1 | HMG-COA reductase inhibitors | MERCK & CO. INC. (US) | 1989-08-09 | — | — | EP | disclosed |
| EP-0327166-A1 | Novel HMG-COA reductase inhibitors | MERCK & CO. INC. (US) | 1989-08-09 | — | — | EP | disclosed |