Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.65 |
| ▸ | HPGD | P15428 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31238771 | 1.00 | KDM4E (0.65) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL1485475 | 0.86 | KDM4E (0.68) | KDM4EALDH1A1HPGDMAPTGAA | |
| SCHEMBL1485283 | 0.84 | KDM4E (0.67) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL31521365 | 0.83 | KDM4E (0.65) | KDM4EALDH1A1NPC1RAB9ACSNK1A1 | |
| SCHEMBL16862868 | 0.83 | KDM4E (0.65) | KDM4EALDH1A1GAACSNK1A1TYRO3 | |
| SCHEMBL16862898 | 0.83 | KDM4E (0.65) | KDM4EALDH1A1CSNK1A1TYRO3DYRK1B | |
| SCHEMBL22530491 | 0.82 | KDM4E (0.63) | KDM4EALDH1A1CSNK1A1TYRO3DYRK1B | |
| SCHEMBL29140743 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL9503741 | 0.79 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDMAPTNPSR1 | |
| SCHEMBL3062520 | 0.78 | KDM4E (0.70) | KDM4EALDH1A1KDM6BKDM5CKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117980307-A | Substituted tricyclic compounds as PARP inhibitors and application thereof | 上海瑛派药业有限公司 | 2024-05-03 | — | — | CN | disclosed |
| EP-0543865-A1 | BENZAMIDE DERIVATIVES | RHONE-POULENC RORER LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |