Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30863327 | 0.82 | VCAM1 (0.66) | ALDH1A1KDM4EVCAM1HPGDNPSR1 | |
| SCHEMBL1485475 | 0.81 | KDM4E (0.68) | ALDH1A1KDM4EHPGDMAPTPOLB | |
| SCHEMBL1485283 | 0.80 | KDM4E (0.67) | ALDH1A1KDM4EHPGDMAPTLMNA | |
| SCHEMBL31238771 | 0.79 | KDM4E (0.65) | ALDH1A1KDM4EHPGDNPSR1MAPT | |
| SCHEMBL16862868 | 0.79 | KDM4E (0.65) | ALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL9502193 | 0.79 | KDM4E (0.65) | ALDH1A1KDM4EHPGDNPSR1MAPT | |
| SCHEMBL16862898 | 0.79 | KDM4E (0.65) | ALDH1A1KDM4E | |
| SCHEMBL8536432 | 0.79 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPTPOLBMAPK1 | |
| SCHEMBL31521365 | 0.79 | KDM4E (0.65) | ALDH1A1KDM4ELMNA | |
| SCHEMBL17197998 | 0.78 | VCAM1 (0.61) | ALDH1A1KDM4EVCAM1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4392425-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS PARP INHIBITORS AND USE THEREOF | Impact Therapeutics (Shanghai), Inc. (CN) | 2024-07-03 | — | — | EP | disclosed |
| CN-117980307-A | Substituted tricyclic compounds as PARP inhibitors and application thereof | 上海瑛派药业有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023025307-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS AS PARP INHIBITORS AND USE THEREOF | IMPACT THERAPEUTICS (SHANGHAI) , INC (CN) | 2023-03-02 | — | — | WO | disclosed |
| EP-0543865-A1 | BENZAMIDE DERIVATIVES | RHONE-POULENC RORER LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |