Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | PGR | P06401 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | CACNA1B | Q00975 | 8/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502245 | 1.00 | LMNA (0.64) | LMNANR1I2ADORA3PDE4DHTT | |
| SCHEMBL10495738 | 0.90 | LMNA (0.76) | LMNANR1I2ADORA3PDE4DHTT | |
| SCHEMBL8595500 | 0.90 | LMNA (0.76) | LMNANR1I2ADORA3PDE4DHTT | |
| SCHEMBL8595497 | 0.90 | LMNA (0.76) | LMNANR1I2ADORA3PDE4DHTT | |
| SCHEMBL9873105 | 0.84 | CYP2C9 (0.74) | LMNANR1I2ADORA3PDE4DHTT | |
| SCHEMBL9502769 | 0.84 | LMNA (0.65) | LMNANR1I2ADORA3PDE4DHTT | |
| SCHEMBL9873112 | 0.84 | CYP2C9 (0.74) | LMNANR1I2ADORA3PDE4DHTT | |
| SCHEMBL9502762 | 0.84 | LMNA (0.65) | LMNANR1I2ADORA3PDE4DHTT | |
| SCHEMBL9501997 | 0.84 | LMNA (0.67) | LMNANR1I2ADORA3PDE4DHTT | |
| SCHEMBL9501988 | 0.84 | LMNA (0.67) | LMNANR1I2ADORA3PDE4DHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0242950-B1 | DIHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS THERAPEUTICS | GLAXO S.p.A. (IT) | 1993-05-26 | — | — | EP | claimed |
| US-4935548-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | GLAXO S.P.A (IT) | 1990-06-19 | — | — | US | claimed |
| EP-0242950-A2 | dihydropyridines, process for their preparation and their use as therapeutics | GLAXO S.p.A. (IT) | 1987-10-28 | — | — | EP | claimed |
| EP-0242950-B1 | DIHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS THERAPEUTICS | GLAXO S.p.A. (IT) | 1993-05-26 | — | — | EP | disclosed |
| US-4935548-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | GLAXO S.P.A (IT) | 1990-06-19 | — | — | US | disclosed |
| EP-0242950-A2 | dihydropyridines, process for their preparation and their use as therapeutics | GLAXO S.p.A. (IT) | 1987-10-28 | — | — | EP | disclosed |