Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 7/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.74 |
| ▸ | LMNA | P02545 | 4/20 | 0.74 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.74 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.74 |
| ▸ | PGR | P06401 | 2/20 | 0.74 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.74 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.74 |
| ▸ | DRD3 | P35462 | 1/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9873105 | 1.00 | CYP2C9 (0.74) | CYP2C9ADORA3CYP3A4CYP2C19LMNA | |
| SCHEMBL8595497 | 0.94 | LMNA (0.76) | CYP2C9ADORA3CYP3A4CYP2C19LMNA | |
| SCHEMBL8595500 | 0.94 | LMNA (0.76) | CYP2C9ADORA3CYP3A4CYP2C19LMNA | |
| SCHEMBL10495738 | 0.94 | LMNA (0.76) | CYP2C9ADORA3CYP3A4CYP2C19LMNA | |
| SCHEMBL29261988 | 0.90 | ADORA3 (0.92) | CYP2C9ADORA3CYP3A4CYP2C19LMNA | |
| SCHEMBL29262164 | 0.90 | ADORA3 (0.92) | CYP2C9ADORA3CYP3A4CYP2C19LMNA | |
| SCHEMBL29285310 | 0.90 | ADORA3 (0.92) | CYP2C9ADORA3CYP3A4CYP2C19LMNA | |
| SCHEMBL9871528 | 0.85 | ADORA3 (0.57) | CYP2C9ADORA3CYP3A4CYP2C19LMNA | |
| SCHEMBL9871535 | 0.85 | ADORA3 (0.57) | CYP2C9ADORA3CYP3A4CYP2C19LMNA | |
| SCHEMBL9502762 | 0.85 | LMNA (0.65) | CYP2C9ADORA3CYP3A4CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011848-A | Cardiovascular disorders, hypotensive agents | GLAXO, S.P.A. (IT) | 1991-04-30 | — | — | US | disclosed |
| US-4801599-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS | GLAXO S.P.A. (IT) | 1989-01-31 | — | — | US | disclosed |