Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | METAP2 | P50579 | 3/20 | 0.46 |
| ▸ | METAP1 | P53582 | 2/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10659068 | 1.00 | ALDH1A1 (0.46) | ALDH1A1METAP2METAP1SLC1A3SLC1A2 | |
| SCHEMBL7275103 | 1.00 | ALDH1A1 (0.46) | ALDH1A1METAP2METAP1SLC1A3SLC1A2 | |
| SCHEMBL7151431 | 0.85 | REN (0.47) | ALDH1A1METAP2METAP1SLC1A3SLC1A2 | |
| SCHEMBL21690082 | 0.85 | REN (0.47) | ALDH1A1METAP2METAP1SLC1A3SLC1A2 | |
| SCHEMBL272993 | 0.85 | REN (0.47) | ALDH1A1METAP2METAP1SLC1A3SLC1A2 | |
| SCHEMBL3998377 | 0.84 | ALDH1A1 (0.42) | ALDH1A1METAP2METAP1SLC1A3SLC1A2 | |
| SCHEMBL3995997 | 0.84 | ALDH1A1 (0.42) | ALDH1A1METAP2METAP1SLC1A3SLC1A2 | |
| SCHEMBL4001477 | 0.84 | ALDH1A1 (0.42) | ALDH1A1METAP2METAP1SLC1A3SLC1A2 | |
| SCHEMBL289091 | 0.82 | DPP4 (0.53) | ALDH1A1METAP2METAP1SLC1A3SLC1A2 | |
| SCHEMBL27999732 | 0.82 | DPP4 (0.53) | ALDH1A1METAP2METAP1SLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161588-A2 | Diamino acid derivatives | MERCK PATENT GmbH (DE) | 1985-11-21 | — | — | EP | claimed |
| EP-0198271-B1 | PEPTIDES | MERCK PATENT GmbH (DE) | 1993-06-09 | — | — | EP | disclosed |
| US-5215966-A | For treatment of hypertension, hyperaldosteronism and cardiac insufficiency | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-06-01 | — | — | US | disclosed |
| EP-0161588-B1 | DIAMINO ACID DERIVATIVES | MERCK PATENT GmbH (DE) | 1990-08-16 | — | — | EP | disclosed |
| US-4829053-A | Amino acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1989-05-09 | — | — | US | disclosed |
| US-4755592-A | Statine-containing peptides useful in medicaments | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1988-07-05 | — | — | US | disclosed |
| US-4721776-A | Amino acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1988-01-26 | — | — | US | disclosed |