Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Thioglycolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thioglycolic Acid SCHEMBL17075358 | 0.87 | POLB (0.38) | POLBPTGS1PDE4AAPEX1FOLH1 | |
| Thioglycolic Acid SCHEMBL134322 | 0.84 | LMNA (0.46) | PTGS1FOLH1LMNALDHASRR | |
| Thioglycolic Acid SCHEMBL21017 | 0.84 | — | — | |
| Thioglycolic Acid SCHEMBL10796026 | 0.81 | — | — | |
| Thioglycolic Acid SCHEMBL7033331 | 0.81 | — | — | |
| Thioglycolic Acid SCHEMBL9357348 | 0.81 | — | — | |
| Thioglycolic Acid SCHEMBL10815859 | 0.81 | — | — | |
| Thioglycolic Acid SCHEMBL60835 | 0.81 | — | — | |
| Thioglycolic Acid SCHEMBL16760983 | 0.81 | — | — | |
| Thioglycolic Acid SCHEMBL3273734 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0331821-B1 | ANTIVIRAL AGENT | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1993-05-19 | — | — | EP | disclosed |
| EP-0331821-A1 | Antiviral agent | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-09-13 | — | — | EP | disclosed |
| US-4663438-A | ANTITUMOR AGENTS | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1987-05-05 | — | — | US | disclosed |
| EP-0058093-B1 | GLYCOPROTEIN HAVING ANTI-TUMOUR AND LECTIN-LIKE ACTIVITY | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1984-10-24 | — | — | EP | disclosed |
| EP-0058093-A1 | Glycoprotein having anti-tumour and lectin-like activity | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1982-08-18 | — | — | EP | disclosed |
| US-4087328-A | PRECIPITATION FROM WHEY | RESEARCH TRIANGLE INSTITUTE (US) | 1978-05-02 | — | — | US | disclosed |