Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Dicyclohexylcarbodiimide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 5/20 | 0.34 |
| ▸ | CA12 | O43570 | 4/20 | 0.34 |
| ▸ | CA1 | P00915 | 4/20 | 0.34 |
| ▸ | CA2 | P00918 | 4/20 | 0.34 |
| ▸ | CA9 | Q16790 | 4/20 | 0.34 |
| ▸ | MMP1 | P03956 | 3/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dicyclohexylcarbodiimide SCHEMBL10525266 | 0.85 | EPHX1 (0.88) | EPHX1HIF1AALDH1A1CYP1A2 | |
| Dicyclohexylcarbodiimide SCHEMBL3173433 | 0.84 | EPHX1 (1.00) | EPHX1HIF1AALDH1A1CYP1A2 | |
| SCHEMBL11842065 | 0.84 | EPHX1 (1.00) | EPHX1HIF1AALDH1A1CYP1A2 | |
| SCHEMBL15667923 | 0.84 | EPHX1 (1.00) | EPHX1HIF1AALDH1A1CYP1A2 | |
| SCHEMBL21986399 | 0.84 | EPHX1 (1.00) | EPHX1HIF1AALDH1A1CYP1A2 | |
| Dicyclohexylcarbodiimide SCHEMBL303 | 0.84 | EPHX1 (1.00) | EPHX1HIF1AALDH1A1CYP1A2 | |
| Dicyclohexylcarbodiimide SCHEMBL6562189 | 0.84 | EPHX1 (0.50) | EPHX1HIF1AALDH1A1 | |
| Dicyclohexylcarbodiimide SCHEMBL6562192 | 0.84 | EPHX1 (0.50) | EPHX1HIF1AALDH1A1 | |
| Dicyclohexylcarbodiimide SCHEMBL3757858 | 0.82 | EPHX1 (0.83) | EPHX1HIF1AALDH1A1CYP1A2 | |
| Dicyclohexylcarbodiimide SCHEMBL1073570 | 0.82 | EPHX1 (0.94) | EPHX1HIF1AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109666161-A | A kind of energy-absorbing method based on dynamic aggregation object | 翁秋梅 | 2019-04-23 | — | — | CN | disclosed |
| CN-109666157-A | A kind of hydridization dynamic aggregation object and its application | 翁秋梅 | 2019-04-23 | — | — | CN | disclosed |
| EP-0260833-B1 | PROCESS FOR PRODUCING POLYAMIDE ACID HAVING SILOXANE BONDS AND POLYIMIDE HAVING SILOXANE BONDS AND ISOINDOLOQUINAZOLINEDIONE RINGS | HITACHI CHEMICAL COMPANY (JP) | 1993-06-09 | — | — | EP | disclosed |
| US-4847358-A | HEAT RESISTANT ELECTRONICS | HITACHI CHEMICAL COMPANY, LTD. (JP) | 1989-07-11 | — | — | US | disclosed |
| US-4786641-A | HYPOGLYCEMIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1988-11-22 | — | — | US | disclosed |
| EP-0260833-A2 | Process for producing polyamide acid having siloxane bonds and polyimide having siloxane bonds and isoindoloquinazolinedione rings | HITACHI CHEMICAL COMPANY (JP) | 1988-03-23 | — | — | EP | disclosed |