Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8394585 | 0.90 | GBA1 (0.69) | GBA1MAPK1ALDH1A1PKMKDM4E | |
| SCHEMBL8393373 | 0.87 | GBA1 (0.60) | GBA1MAPK1ALDH1A1PKMKDM4E | |
| SCHEMBL8391575 | 0.87 | GBA1 (0.60) | GBA1MAPK1ALDH1A1PKMKDM4E | |
| SCHEMBL8391910 | 0.86 | GBA1 (0.58) | GBA1MAPK1ALDH1A1PKMKDM4E | |
| SCHEMBL8397048 | 0.86 | GBA1 (0.58) | GBA1MAPK1ALDH1A1PKMKDM4E | |
| SCHEMBL9505643 | 0.85 | TBXA2R (0.52) | ALDH1A1KDM4ESMN1; SMN2NPSR1TSHR | |
| SCHEMBL9502716 | 0.84 | GBA1 (0.61) | GBA1MAPK1ALDH1A1PKMKDM4E | |
| SCHEMBL9502721 | 0.83 | GBA1 (0.59) | GBA1MAPK1ALDH1A1PKMKDM4E | |
| SCHEMBL17205770 | 0.83 | GBA1 (0.55) | GBA1MAPK1ALDH1A1PKMKDM4E | |
| SCHEMBL8395503 | 0.81 | ALDH1A1 (0.66) | GBA1MAPK1ALDH1A1PKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361113-B1 | SULFONAMIDOALKYL CYCLOALKANE COMPOUNDS, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS | Roche Diagnostics GmbH (DE) | 1993-07-07 | — | — | EP | disclosed |