SCHEMBL9502670

SCHEMBL9502670

O=C(NCc1ccc(Cl)cc1)C(O)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 1/20 0.55
MEN1 O00255 3/20 0.54
KMT2A Q03164 3/20 0.54
ALDH1A1 P00352 2/20 0.54
LMNA P02545 2/20 0.54
CYP2C19 P33261 2/20 0.51
CYP2C9 P11712 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2D6 P10635 1/20 0.51
PLAAT3 P53816 1/20 0.51
PLAAT5 Q96KN8 1/20 0.51
PLAAT2 Q9NWW9 1/20 0.51
PLAAT4 Q9UL19 1/20 0.51
CNR1 P21554 1/20 0.50
CNR2 P34972 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30132781 1.00 MALT1 (0.55) MALT1MEN1KMT2AALDH1A1LMNA
SCHEMBL10766345 0.94 UTS2R (0.54) MALT1MEN1KMT2AALDH1A1LMNA
SCHEMBL4158853 0.89 KMT2A (0.57) MEN1KMT2ALMNA
SCHEMBL4158848 0.89 KMT2A (0.57) MEN1KMT2ALMNA
SCHEMBL4158947 0.89 KMT2A (0.57) MEN1KMT2ALMNA
SCHEMBL10693686 0.84 ALDH1A1 (0.56) MEN1KMT2AALDH1A1LMNACYP2C19
SCHEMBL29521788 0.84 ALDH1A1 (0.56) MEN1KMT2AALDH1A1LMNACYP2C19
SCHEMBL9501925 0.84 MEN1 (0.75) MEN1KMT2A
SCHEMBL5176252 0.81 MEN1 (0.64) MEN1KMT2ACYP2C19CYP1A2CNR1
SCHEMBL5176623 0.81 MEN1 (0.64) MEN1KMT2ACYP2C19CYP1A2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0376852-B1 MICROGRANULES ESSENTIALLY CONSISTING OF TRIGLYCERIDES OF SATURATED FATTY ACIDS LOADED WITH AN ACTIVE SUBSTANCE, AND THEIR TOPICAL THERAPEUTICAL USE CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) 1993-06-23 EP claimed
EP-0376852-A1 Microgranules essentially consisting of triglycerides of saturated fatty acids loaded with an active substance, and their topical therapeutical use CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) 1990-07-04 EP claimed
EP-0098743-B1 PHENYL ALPHA-ACYLOXYACETAMIDE DERIVATES AND THEIR THERAPEUTIC USE Yu, Ruey J., Dr. (US) 1988-09-28 EP claimed
EP-0098743-A1 Phenyl alpha-acyloxyacetamide derivates and their therapeutic use Yu, Ruey J., Dr. (US) 1984-01-18 EP claimed
EP-0376852-B1 MICROGRANULES ESSENTIALLY CONSISTING OF TRIGLYCERIDES OF SATURATED FATTY ACIDS LOADED WITH AN ACTIVE SUBSTANCE, AND THEIR TOPICAL THERAPEUTICAL USE CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) 1993-06-23 EP disclosed
EP-0463962-A1 Preparation of fatty product microspheres loaded or not with an active substance CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) 1992-01-02 EP disclosed
EP-0376852-A1 Microgranules essentially consisting of triglycerides of saturated fatty acids loaded with an active substance, and their topical therapeutical use CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) 1990-07-04 EP disclosed
EP-0098743-B1 PHENYL ALPHA-ACYLOXYACETAMIDE DERIVATES AND THEIR THERAPEUTIC USE Yu, Ruey J., Dr. (US) 1988-09-28 EP disclosed
US-4518789-A Phenyl alpha-acyloxyacetamide derivatives and their therapeutic use YU RUEY J 1985-05-21 US disclosed
EP-0098743-A1 Phenyl alpha-acyloxyacetamide derivates and their therapeutic use Yu, Ruey J., Dr. (US) 1984-01-18 EP disclosed