Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP24A1 | Q07973 | 6/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | CYP27A1 | Q02318 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9133466 | 0.99 | CYP24A1 (0.47) | CYP24A1CYP26A1ADRB2ADRB1ADRA1D | |
| SCHEMBL9501745 | 0.86 | ADRB2 (0.55) | ADRB2ADRB1ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL9135234 | 0.85 | ADRB2 (0.54) | ADRB2ADRB1ADRA1DADRA1AADRA1B | |
| SCHEMBL9505712 | 0.83 | ADRB2 (0.49) | CYP24A1CYP26A1ADRB2ADRB1ADRA1A | |
| SCHEMBL9504946 | 0.83 | ADRB2 (0.49) | CYP24A1CYP26A1ADRB2ADRB1ADRA1A | |
| SCHEMBL9501706 | 0.83 | ADRB2 (0.49) | CYP24A1CYP26A1ADRB2ADRB1ADRA1A | |
| SCHEMBL9501699 | 0.83 | ADRB2 (0.49) | CYP24A1CYP26A1ADRB2ADRB1ADRA1A | |
| SCHEMBL9505720 | 0.83 | ADRB2 (0.49) | CYP24A1CYP26A1ADRB2ADRB1ADRA1A | |
| SCHEMBL9504754 | 0.83 | CYP24A1 (0.51) | CYP24A1CYP26A1ADRB1ADRB3ACHE | |
| Hydrochloric Acid SCHEMBL9134833 | 0.82 | ADRB2 (0.48) | CYP24A1CYP26A1ADRB2ADRB1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549668-A1 | ANTI-HYPERTENSIVE TETRALINS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-07-07 | — | — | EP | claimed |
| WO-1992005143-A1 | ANTI-HYPERTENSIVE TETRALINS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-04-02 | — | — | WO | claimed |