Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 12/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 11/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 11/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 11/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 11/20 | 0.55 |
| ▸ | ADRB3 | P13945 | 10/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9135234 | 0.99 | ADRB2 (0.54) | ADRB2ADRB1ADRA1DADRA1AADRA1B | |
| SCHEMBL9503471 | 0.89 | ADRB2 (0.55) | ADRB2ADRB1ADRA1DADRA1AADRA1B | |
| SCHEMBL9502729 | 0.86 | CYP24A1 (0.48) | ADRB2ADRB1ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL9133466 | 0.85 | CYP24A1 (0.47) | ADRB2ADRB1ADRA1DADRA1AADRA1B | |
| SCHEMBL9703210 | 0.82 | ALDH1A1 (0.65) | ALDH1A1CYP2D6CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL9504971 | 0.82 | ALDH1A1 (0.55) | ADRB2ADRB1ADRA1AADRA1BADRB3 | |
| SCHEMBL9504939 | 0.81 | ALDH1A1 (0.49) | ADRB3ALDH1A1CYP2D6CYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL9133377 | 0.80 | ALDH1A1 (0.48) | ADRB3ALDH1A1CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL9504910 | 0.79 | ALDH1A1 (0.52) | ADRB1ADRB3ALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL9503443 | 0.79 | ADRB2 (0.49) | ADRB2ADRB1ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549668-A1 | ANTI-HYPERTENSIVE TETRALINS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-07-07 | — | — | EP | claimed |
| WO-1992005143-A1 | ANTI-HYPERTENSIVE TETRALINS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-04-02 | — | — | WO | claimed |