Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 5/20 | 0.33 |
| ▸ | THRA | P10827 | 4/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9500270 | 0.84 | MEN1 (0.42) | GPR17 | |
| SCHEMBL9499194 | 0.83 | GPR17 (0.33) | GPR17 | |
| SCHEMBL9499303 | 0.82 | KDM4E (0.35) | THRBTHRAGPR17 | |
| SCHEMBL9500217 | 0.80 | MEN1 (0.44) | — | |
| SCHEMBL9452365 | 0.80 | MEN1 (0.48) | — | |
| SCHEMBL9500993 | 0.78 | KDM4E (0.37) | GPR17 | |
| SCHEMBL9501376 | 0.77 | GRIN1 (0.43) | — | |
| SCHEMBL9452362 | 0.76 | KDM4E (0.46) | — | |
| SCHEMBL9499178 | 0.74 | EGLN1 (0.33) | THRBGPR17 | |
| SCHEMBL9501069 | 0.73 | DAO (0.40) | DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303387-B1 | KYNURENIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | MERCK SHARP & DOHME LTD. (GB) | 1993-04-21 | — | — | EP | claimed |