Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9499303 | 0.83 | KDM4E (0.35) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL9499254 | 0.83 | MEN1 (0.44) | MEN1GRIN2DGRIN3BCYP1A2CYP2D6 | |
| SCHEMBL9501376 | 0.81 | GRIN1 (0.43) | MEN1GRIN2DGRIN3BCYP1A2CYP2D6 | |
| SCHEMBL9499243 | 0.80 | MEN1 (0.44) | MEN1GRIN2DGRIN3BCYP1A2CYP2D6 | |
| SCHEMBL9502839 | 0.80 | THRB (0.33) | — | |
| SCHEMBL9452324 | 0.78 | MEN1 (0.72) | MEN1GRIN2DGRIN3BCYP1A2CYP2D6 | |
| SCHEMBL9502875 | 0.78 | GRIN2D (0.41) | MEN1GRIN2DGRIN3BCYP1A2CYP2D6 | |
| SCHEMBL9499688 | 0.74 | MEN1 (0.44) | MEN1GRIN2DGRIN3BCYP1A2CYP2D6 | |
| SCHEMBL9499178 | 0.74 | EGLN1 (0.33) | MEN1CYP1A2CYP2D6HPGDBLM | |
| SCHEMBL9499194 | 0.72 | GPR17 (0.33) | GRIN2DGRIN3BCYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303387-B1 | KYNURENIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | MERCK SHARP & DOHME LTD. (GB) | 1993-04-21 | — | — | EP | claimed |