Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 7/20 | 0.44 |
| ▸ | THRB | P10828 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPRB | P23467 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | CDC25A | P30304 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8732769 | 0.79 | PTPN1 (0.60) | PTPN1 | |
| SCHEMBL9063248 | 0.78 | PTPN1 (0.58) | PTPN1CYP2C19CYP2C9THRATHRB | |
| SCHEMBL9503696 | 0.78 | TSHR (0.51) | PTPN1CYP2C19CYP2C9THRATHRB | |
| SCHEMBL14639528 | 0.78 | PTPN1 (0.58) | PTPN1CYP2C19CYP2C9THRATHRB | |
| SCHEMBL4651749 | 0.78 | PTPN1 (0.58) | PTPN1CYP2C19CYP2C9MEN1KMT2A | |
| Phenoxymethylphosphonate SCHEMBL274327 | 0.77 | CYP2C9 (0.76) | PTPN1CYP2C19CYP2C9THRATHRB | |
| SCHEMBL14092562 | 0.77 | PTPN1 (0.41) | PTPN1CYP2C19CYP2C9MEN1KMT2A | |
| SCHEMBL9665015 | 0.76 | CYP2C19 (0.61) | PTPN1CYP2C19CYP2C9GAAPTPRC | |
| SCHEMBL8727070 | 0.75 | PTPN1 (0.55) | PTPN1ADRB2ADRB3 | |
| SCHEMBL8727063 | 0.75 | PTPN1 (0.55) | PTPN1ADRB2ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0550574-A1 | HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005180-A1 | HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-04-02 | — | — | WO | disclosed |