Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | ACP3 | P15309 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 2/20 | 0.41 |
| ▸ | IDO2 | Q6ZQW0 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11606505 | 0.81 | TSHR (0.50) | ADRB2ADRB1AOC3HIF1ACYP2D6 | |
| SCHEMBL4815784 | 0.79 | TSHR (0.47) | ADRB2ADRB1AOC3HIF1ACYP2D6 | |
| SCHEMBL29976363 | 0.79 | ADRB2 (0.48) | ADRB2ADRB1AOC3HIF1ACYP2D6 | |
| SCHEMBL9677445 | 0.79 | TSHR (0.47) | ADRB2ADRB1AOC3HIF1ACYP2D6 | |
| SCHEMBL6918732 | 0.79 | ADRB2 (0.48) | ADRB2ADRB1AOC3HIF1ACYP2D6 | |
| SCHEMBL230382 | 0.79 | ADRB2 (0.48) | ADRB2ADRB1AOC3HIF1ACYP2D6 | |
| SCHEMBL456765 | 0.77 | ADRB2 (0.47) | ADRB2ADRB1AOC3HIF1ACYP2D6 | |
| SCHEMBL4167758 | 0.77 | TSHR (0.47) | ADRB2ADRB1AOC3HIF1ACYP2D6 | |
| SCHEMBL29413799 | 0.76 | ADRB2 (0.43) | ADRB2ADRB1AOC3HIF1ACYP2D6 | |
| SCHEMBL136204 | 0.76 | ADRB2 (0.43) | ADRB2ADRB1AOC3HIF1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104744227-A | 5-bromine-2-chlorobenzaldehyde preparation method | PORTON FINE CHEMICALS LTD | 2015-07-01 | — | — | CN | claimed |
| CN-110191879-A | A kind of histone methyltransferase EZH2 inhibitor, preparation method and its medical usage | 恩瑞生物医药科技（上海）有限公司 | 2019-08-30 | — | — | CN | disclosed |
| CN-105829305-B | NRF2 regulator | 葛兰素史密斯克莱知识产权发展有限公司 | 2018-11-30 | — | — | CN | disclosed |
| CN-105793238-A | Substituted benzamides and methods of use thereof | 基因泰克公司 | 2016-07-20 | — | — | CN | disclosed |
| CN-104744227-A | 5-bromine-2-chlorobenzaldehyde preparation method | PORTON FINE CHEMICALS LTD | 2015-07-01 | — | — | CN | disclosed |
| CN-104109154-A | C-aryl glucoside derivative, preparation method and applications thereof | SHANGHAI SUN SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO LTD | 2014-10-22 | — | — | CN | disclosed |
| CN-104109155-A | Novel compounds | TANABE SEIYAKU CO | 2014-10-22 | — | — | CN | disclosed |
| CN-103819465-A | Novel compound | MITSUBISHI TANABE PHARMA CORP | 2014-05-28 | — | — | CN | disclosed |
| CN-103772449-A | C-aryl glucoside derivative as well as preparation method and application thereof | SHANGHAI SUN SAIL PHARMACEUTICAL SCIENCE & TECHNOLOGY CO LTD | 2014-05-07 | — | — | CN | disclosed |
| WO-1993008166-A1 | BENZO-ISOQUINOLINE DERIVATIVES AND ANALOGS AND THEIR USE IN THERAPEUTICS | THE UPJOHN COMPANY (US) | 1993-04-29 | — | — | WO | disclosed |
| EP-0539209-A1 | Benzo-isoquinoline derivatives and analogs and their use in therapeutics | THE UPJOHN COMPANY (US) | 1993-04-28 | — | — | EP | disclosed |