Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4815784 | 0.81 | TSHR (0.47) | TSHRHIF1ALMNACYP2C19CYP3A4 | |
| SCHEMBL9677445 | 0.81 | TSHR (0.47) | TSHRHIF1ALMNACYP2C19CYP3A4 | |
| SCHEMBL30848757 | 0.78 | TSHR (0.50) | TSHRHIF1ALMNACYP2C19CYP3A4 | |
| SCHEMBL947512 | 0.78 | TSHR (0.50) | TSHRHIF1ALMNACYP2C19CYP3A4 | |
| SCHEMBL11617245 | 0.78 | TSHR (0.50) | TSHRHIF1ALMNACYP2C19CYP3A4 | |
| SCHEMBL320794 | 0.77 | P2RX7 (0.47) | TSHRHIF1ALMNACYP2C19CYP3A4 | |
| SCHEMBL13145151 | 0.77 | P2RX7 (0.47) | TSHRHIF1ALMNACYP2C19CYP3A4 | |
| SCHEMBL5627145 | 0.77 | TSHR (0.43) | TSHRHIF1ALMNACYP2C19CYP3A4 | |
| SCHEMBL9503376 | 0.77 | ADRB2 (0.46) | TSHRHIF1ALMNACYP2C19CYP3A4 | |
| SCHEMBL8651062 | 0.76 | TSHR (0.47) | TSHRHIF1ALMNACYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115784972-A | Ethylene diamine derivative and preparation method and application thereof | 江苏普莱医药生物技术有限公司 | 2023-03-14 | — | — | CN | claimed |
| EP-1773934-A2 | NOVEL FIRE RETARDANTS | Bromine Compounds Ltd. (IL) | 2007-04-18 | — | — | EP | claimed |
| WO-2006006154-A2 | NOVEL FIRE RETARDANTS | BROMINE COMPOUNDS LTD. (IL) | 2006-01-19 | — | — | WO | claimed |
| CN-115594669-A | Fused ring derivative and preparation method and medical application thereof | 深圳信立泰药业股份有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |
| CN-114181207-B | Beta-carboline compounds, preparation method thereof and application thereof in resisting Alzheimer disease | 中国人民解放军北部战区总医院 | 2022-12-13 | — | — | CN | disclosed |
| CN-114975904-A | Polyoxometalate-based viologen polymer derived carbide composite material and preparation method and application thereof | 上海应用技术大学 | 2022-08-30 | — | — | CN | disclosed |
| WO-2022123530-A1 | BORONIC ACID COMPOUND | 주식회사 엘지화학 | 2022-06-16 | — | — | WO | disclosed |
| CN-109111463-A | The manufacturing method of aromatic compound | DIC株式会社 | 2019-01-01 | — | — | CN | disclosed |
| CN-103214471-B | The preparation method of compound with Na-dependent glucose transporter inhibitory activity | 田边三菱制药株式会社 | 2018-02-06 | — | — | CN | disclosed |
| WO-2009033689-A1 | PIPERIDONE DERIVATIVES AND MEDICAL USES THEREOF | HEINRICH-PETTE-INSTITUT (DE) | 2009-03-19 | — | — | WO | disclosed |
| EP-2036556-A1 | Piperidone derivatives and medical uses thereof | Heinrich-Pette-Institut (DE) | 2009-03-18 | — | — | EP | disclosed |
| US-6140344-A | FOR TREATING PATHOLOGICAL CONDITIONS SUCH AS ASTHMA, RHINITIS, ECZEMA AND PARASITIC INFECTIONS FEATURING TISSUE EOSINOPHILIA | SYNTEX (U.S.A.) INC. (US) | 2000-10-31 | — | — | US | disclosed |
| US-6093696-A | N-ACETYL-D-THIOPROLINE-(O-2,6-DICHLOROBENZYL)-L-TYROSINE, FOR EXAMPLE; SELECTIVELY INHIBIT THE ALPHA 4 SUBGROUP OF INTEGRINS FROM BINDING TO THEIR LIGANDS; USE IN PROPHYLAXIS OR TREATMENT OF IMMUNE OR INFLAMMATORY DISEASES | CELLTECH THERAPEUTICS, LIMITED (GB) | 2000-07-25 | — | — | US | disclosed |
| WO-2000031033-A1 | PIPERIDINE CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-02 | — | — | WO | disclosed |
| WO-2000029377-A1 | 4-AROYL-PIPERIDIN-CCR-3 RECEPTOR ANTAGONISTS III | F. HOFFMANN-LA ROCHE AG (CH) | 2000-05-25 | — | — | WO | disclosed |
| EP-0984981-A1 | ANTI-INFLAMMATORY TYROSINE DERIVATIVES | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-03-15 | — | — | EP | disclosed |
| EP-0903349-A2 | CCR-3 receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-24 | — | — | EP | disclosed |
| WO-1998054207-A1 | ANTI-INFLAMMATORY TYROSINE DERIVATIVES | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-12-03 | — | — | WO | disclosed |
| US-5234917-A | Hypotensive agent, treatment of renal failure or glaucoma | SMITHKLINE BEECHAM CORPORATION | 1993-08-10 | — | — | US | disclosed |
| EP-0220810-A1 | Insecticidal ethers | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-05-06 | — | — | EP | disclosed |