Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 6/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9500924 | 0.89 | EPHX2 (0.47) | EPHX2NR1H4PDK1PDK2PDK3 | |
| SCHEMBL5809008 | 0.85 | EPHX2 (0.51) | EPHX2NR1H4PDK1PDK2PDK3 | |
| SCHEMBL8721476 | 0.78 | NPC1 (0.59) | MEN1RAB9AKMT2ALMNA | |
| SCHEMBL6056652 | 0.75 | MAOB (0.49) | MAPTALDH1A1RAB9AKMT2ATSHR | |
| SCHEMBL10937278 | 0.75 | RXRA (0.50) | ALDH1A1RAB9ATSHR | |
| SCHEMBL6056716 | 0.74 | TSHR (0.52) | ALDH1A1RAB9AKMT2ATSHRLMNA | |
| SCHEMBL17845228 | 0.74 | EPHX2 (0.55) | EPHX2NR1H4MAPTCYP1A2CYP2C9 | |
| SCHEMBL4586654 | 0.73 | TSHR (0.54) | MAPTMEN1ALDH1A1KMT2AFPR2 | |
| SCHEMBL3196647 | 0.73 | TSHR (0.54) | MAPTALDH1A1RAB9ACA1CA2 | |
| SCHEMBL5808533 | 0.72 | MAPT (0.39) | EPHX2NR1H4PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260939-B1 | MOLECULES WITH ANTIBODY COMBINING SITES THAT EXHIBIT CATALYTIC PROPERTIES | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1993-04-28 | — | — | EP | disclosed |
| US-5126258-A | Hydrolysis of polypeptides at predetermined site | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1992-06-30 | — | — | US | disclosed |
| US-5030717-A | Binding site which bind to reactant ligand, stabilization | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1991-07-09 | — | — | US | disclosed |
| EP-0260939-A2 | Molecules with antibody combining sites that exhibit catalytic properties | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1988-03-23 | — | — | EP | disclosed |