Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14010366 | 0.88 | MAPT (0.43) | MAPTCYP1A2CYP2C9CYP2C19EPHX2 | |
| SCHEMBL5003839 | 0.77 | CA12 (0.46) | MAPTCYP1A2CYP2C9CYP2C19EPHX2 | |
| SCHEMBL8472320 | 0.76 | PDK1 (0.47) | MAPTCYP1A2CYP2C9CYP2C19EPHX2 | |
| SCHEMBL9503386 | 0.72 | EPHX2 (0.48) | MAPTCYP1A2CYP2C9CYP2C19EPHX2 | |
| SCHEMBL14010410 | 0.72 | MAPT (0.41) | MAPTCYP1A2CYP2C9CYP2C19EPHX2 | |
| SCHEMBL5809008 | 0.70 | EPHX2 (0.51) | MAPTCYP1A2CYP2C9CYP2C19EPHX2 | |
| SCHEMBL13656125 | 0.70 | TSHR (0.60) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL11097805 | 0.69 | KIF11 (0.54) | MAPTCYP1A2CYP2C9CYP2C19CA12 | |
| SCHEMBL5011680 | 0.68 | CA12 (0.49) | MAPTCYP1A2CYP2C9CYP2C19EPHX2 | |
| SCHEMBL28738749 | 0.68 | LMNA (0.65) | MAPTCYP1A2ALDH1A1MEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259520-B1 | NOVEL PURINES | ARIAD PHARMA INC (US) | 2006-05-24 | — | — | EP | disclosed |
| US-20050096298-A1 | Novel perines | METCALF CHESTER A III (US) | 2005-05-05 | — | — | US | disclosed |
| EP-1259520-A2 | NOVEL PURINES | ARIAD PHARMACEUTICALS, INC. (US) | 2002-11-27 | — | — | EP | disclosed |
| US-20020132819-A1 | Novel purinse | ARIAD PHARMACETICALS, INC. | 2002-09-19 | — | — | US | disclosed |
| WO-2001044260-A9 | NOVEL PURINES | ARIAD PHARMA INC (US) | 2002-07-04 | — | — | WO | disclosed |
| WO-2001044260-A2 | NOVEL PURINES | ARIAD PHARMACEUTICALS, INC. (US) | 2001-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096298-A1 | Novel perines | PNP, ENTPD5, NT5C2 | MAPT 4798/4885CYP1A2 4640/4885CYP2C9 4812/4885 |
| US-20020132819-A1 | Novel purinse | PURB, NUDT15, NT5C2 | MAPT 4769/4885CYP1A2 4737/4885CYP2C9 4775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.