Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.53 |
| ▸ | DRD1 | P21728 | 2/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.52 |
| ▸ | DRD3 | P35462 | 6/20 | 0.49 |
| ▸ | DRD4 | P21917 | 5/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9503349 | 0.89 | DRD2 (0.55) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| SCHEMBL9506547 | 0.88 | DRD2 (0.54) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| SCHEMBL9503516 | 0.82 | DRD2 (0.69) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL9711610 | 0.81 | DRD2 (0.67) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| SCHEMBL7391777 | 0.79 | ADRA1D (0.59) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| SCHEMBL7391776 | 0.79 | ADRA1D (0.59) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| SCHEMBL7785750 | 0.78 | DRD2 (0.70) | DRD2DRD1DRD3DRD4HTR1A | |
| SCHEMBL7785753 | 0.78 | DRD2 (0.70) | DRD2DRD1DRD3DRD4HTR1A | |
| SCHEMBL9503568 | 0.77 | DRD2 (0.41) | DRD2DRD1DRD3DRD4HTR1A | |
| SCHEMBL2699278 | 0.76 | DRD2 (0.66) | DRD2DRD3DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321968-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| US-5151414-A | Hypotensive agents | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1992-09-29 | — | — | US | disclosed |
| US-5070106-A | HYPOTENSIVES, CEREBRAL DISORDERS | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1991-12-03 | — | — | US | disclosed |
| EP-0321968-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |