Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.64 |
| ▸ | DRD3 | P35462 | 3/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.64 |
| ▸ | DRD1 | P21728 | 2/20 | 0.64 |
| ▸ | DRD4 | P21917 | 2/20 | 0.64 |
| ▸ | DRD5 | P21918 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9507149 | 0.99 | DRD2 (0.63) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL9504477 | 0.87 | ADRA1D (0.63) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL9504578 | 0.87 | DRD2 (0.66) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL9504628 | 0.86 | ADRA1D (0.61) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL9503718 | 0.86 | DRD2 (0.64) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL9503494 | 0.86 | DRD2 (0.64) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL9504502 | 0.85 | DRD2 (0.63) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL9503531 | 0.85 | ADRA1D (0.63) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL9504438 | 0.81 | ADRA1D (0.69) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL9504430 | 0.81 | ADRA1D (0.68) | DRD2DRD3ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321967-B1 | COMPOUNDS ACTIVE ON THE CARDIOVASCULAR SYSTEM | ZAMBON GROUP S.p.A. (IT) | 1993-07-28 | — | — | EP | disclosed |
| EP-0321967-A2 | Compounds active on the cardiovascular system | ZAMBON GROUP S.p.A. (IT) | 1989-06-28 | — | — | EP | disclosed |