Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852944 | 0.91 | HPGD (0.53) | ALDH1A1KMT2AMEN1TSHRMAPT | |
| SCHEMBL7424373 | 0.85 | KMT2A (0.63) | ALDH1A1KMT2AHSD17B10MEN1NPSR1 | |
| SCHEMBL7260269 | 0.85 | ALDH1A1 (0.54) | ALDH1A1KMT2AHSD17B10MEN1NPSR1 | |
| SCHEMBL1233999 | 0.83 | KMT2A (0.51) | ALDH1A1KMT2AMEN1MAPTGAA | |
| SCHEMBL398553 | 0.82 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1NPSR1MAPT | |
| SCHEMBL31440149 | 0.82 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1NPSR1MAPT | |
| SCHEMBL15679600 | 0.81 | ALDH1A1 (0.55) | ALDH1A1KMT2AHSD17B10MEN1NPSR1 | |
| SCHEMBL9798967 | 0.81 | ALDH1A1 (0.58) | ALDH1A1KMT2AHSD17B10MEN1NPSR1 | |
| SCHEMBL7589770 | 0.80 | HDAC8 (0.59) | ALDH1A1KMT2AHSD17B10MEN1TSHR | |
| SCHEMBL7549194 | 0.80 | HDAC8 (0.59) | ALDH1A1KMT2AHSD17B10MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233413-B1 | 3-(2-AMINOETHYL)INDOLE AND -INDOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1993-05-05 | — | — | EP | disclosed |
| US-4980368-A | CEREBRALVASCULAR DISORDERS; ANTIHYPOXIA AGENTS; COGNITION ACTIVATORS; SENILITY | BEECHAM-WUELFING GMBH & CO. KG (DE) | 1990-12-25 | — | — | US | disclosed |
| EP-0233413-A2 | 3-(2-Aminoethyl)indole and -indoline derivatives, processes for their preparation and pharmaceutical compositions containing them | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1987-08-26 | — | — | EP | disclosed |